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Non-Hodgkin lymphomas of mice. Blood Cells Mol Dis 2001 Jan-Feb;27(1):217-22

Date

05/19/2001

Pubmed ID

11358382

DOI

10.1006/bcmd.2000.0375

Abstract

Studies of lymphoid neoplasms occurring in normal or genetically engineered mice have revealed parallels and differences to non-Hodgkin lymphomas (NHL) of humans. Some mouse lymphomas have strong histologic similarities to the human NHL subsets including precursor B- and T-cell lymphoblastic, small lymphocytic, splenic marginal zone, and diffuse large-cell B-cell lymphomas (DLCL); whether molecular parallels also exist is under study. Others mouse types such as sIg+ lymphoblastic B-cell lymphoma have no histologic equivalent in human NHL even though they share molecular deregulation of BCL6 with human DLCL. Finally, Burkitt lymphoma does not appear to occur naturally in mice, but it can be induced with appropriately engineered transgenes.

Author List

Hori M, Xiang S, Qi CF, Chattopadhyay SK, Fredrickson TN, Hartley JW, Kovalchuk AL, Bornkamm GW, Janz S, Copeland NG, Jenkins NA, Ward JM, Morse HC 3rd

Author

Siegfried Janz MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Burkitt Lymphoma
Humans
Immunoglobulin Heavy Chains
Immunophenotyping
Karyotyping
Lymphoma, B-Cell
Lymphoma, Non-Hodgkin
Lymphoma, T-Cell
Mice
Models, Animal
Tumor Cells, Cultured