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Chromosomes 1 and 5 harbor plasmacytoma progressor genes in mice. Genes Chromosomes Cancer 2000 Sep;29(1):70-4

Date

08/05/2000

Pubmed ID

10918396

DOI

10.1002/1098-2264(2000)9999:9999<::aid-gcc1009>3.0.co;2-c

Abstract

Mouse spectral karyotyping (SKY) was employed to analyze 29 primary BALB/c plasmacytomas (PCTs) for the presence of chromosomal aberrations that took place subsequent to the Myc-activating T(12F1;15D2) or T(6C1;15D2) translocations, the initiating oncogenic mutations in plasmacytomagenesis. Recurrent amplifications of chromosome (Chr) 1 (48% prevalence) and promiscuous non-reciprocal translocations of Chr 5 (52% prevalence) suggested the existence of important PCT progressor genes on bands 1B/C and 5F. The additional occurrence of sporadic aberrations (93% prevalence) most likely reflected the general instability of the PCT genome. This instability, however, was not consistent, as two PCTs lacked secondary cytogenetic changes detectable by SKY. Our findings led us to conclude that BALB/c PCTs show a remarkably similar degree of cytogenetic heterogeneity to human multiple myeloma, despite being genetically defined (inbred mouse strain) and uniformly initiated (deregulation of Myc). Published 2000 Wiley-Liss, Inc.

Author List

Coleman AE, Ried T, Janz S

Author

Siegfried Janz MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aneuploidy
Animals
Chromosome Aberrations
Disease Models, Animal
Disease Progression
Genes, myc
Humans
Karyotyping
Mice
Mice, Inbred BALB C
Multiple Myeloma
Plasmacytoma
Proto-Oncogene Proteins c-myc
Translocation, Genetic
Trinucleotide Repeat Expansion