The effect of non-ionic surfactants on the SOS-inducing potency of 4-nitroquinoline-1-oxide in Escherichia coli PQ37. J Basic Microbiol 1990;30(6):435-42
Date
01/01/1990Pubmed ID
2126282DOI
10.1002/jobm.3620300614Scopus ID
2-s2.0-0025151497 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Various non-ionic surfactants affect the SOS-inducing potency (SOSIP) of the model genotoxin, 4-nitroquinoline-1-oxide, in Escherichia coli PQ37 to varying degrees, as measured by an automated version of the SOS chromotest. While there is little effect on the SOSIP value and other test parameters from Tween 20 and 80 and, with some reservation, Triton X305 and Tyloxapol, over the critical micelle concentration range, the SOSIP value increases in the presence of comparable concentrations of Triton X15, 45 and 100. A possible dependence of the tester strain's beta-galactosidase production and its growth inhibition on the HLB of the non-ionic surfactants added is discussed.
Author List
Raabe F, Janz S, Wolff GAuthor
Siegfried Janz MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
4-Nitroquinoline-1-oxideEscherichia coli
Mutagenicity Tests
Octoxynol
Polyethylene Glycols
Polysorbates
Regression Analysis
Structure-Activity Relationship
Surface-Active Agents