Gas chromatographic-mass spectrometric investigation of four commercial pristane (2.6.10.14-tetramethylpentadecane) preparations used for plasmacytoma induction in BALB/c mice. Arch Geschwulstforsch 1989;59(6):415-22
Date
01/01/1989Pubmed ID
2596957Scopus ID
2-s2.0-0024446035 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
The most widely studied model of plasmacytomagenesis is the induction of plasmacytomas by intraperitoneal injections of pure alkanes such as pristane (2.6.10.14-tetramethylpentadecane). The presence of small amounts of genotoxic contaminants, that could contribute to the complex oncogenic process, in commercial pristane preparations has not been completely ruled out. Therefore, we conducted a chemical analysis of different pristane preparations applying a combined GC/MS technique, but were not capable of identifying any obvious or putative genotoxic/cancerogenic contaminants.
Author List
Janz S, Birkenfeld T, Herzschuh R, Storch HAuthor
Siegfried Janz MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCarcinogens
Drug Contamination
Gas Chromatography-Mass Spectrometry
Mice
Mice, Inbred BALB C
Plasmacytoma
Terpenes