Faculty Collaboration Database

Genotoxicity assessment of the plasmacytomagenic agent pristane (2.6.10.14-tetramethylpentadecane) and four related alkanes by the SOS chromotest. Arch Geschwulstforsch 1988;58(2):73-8

Date

01/01/1988

Pubmed ID

3288166

Scopus ID

2-s2.0-0023907912 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

The most extensively studied model of plasmacytomagenesis is the induction of plasmacytomas in BALB/c mice by i.p. injections of mineral oil or, chemically more defined, by several branched alkanes such as pristane (2.6.10.14-tetramethylpentadecane), phytane (2.6.10.14-tetramethylhexadecane), and 7-n-hexyloctadecane. The available evidence suggests that the primary biologic action of these plasmacytomagenic agents is to induce the formation of a chronic granulomatous tissue, the histological matrix of plasmacytoma development. However, certain genotoxic effects caused by the presence of these substances can not be ruled out a priori. Pristane, 2-methyldodecane, and 1.3-di-tert-butyl-5-methyl-cyclohexane as well as perhydroanthracene and hexahydrodibenzsuberane were proofed as potential genotoxic agents by the SOS chromotest, a quantitative bacterial colorimetric assay for genotoxins. The substances tested did not express any sign of genotoxicity, but exerted toxic effects to the E. coli tester strain.

Author List

Janz S, Huttunen T, Herzschuh R, Storch H

Author

Siegfried Janz MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Alkanes
Anthracenes
Carcinogens
Cycloheptanes
Cyclohexanes
DNA Damage
DNA Repair
Escherichia coli
Mutagenicity Tests
Plasmacytoma
Terpenes