Faculty Collaboration Database

The Role of Micronutrients in Graft-VS.-Host Disease: Immunomodulatory Effects of Vitamins A and D. Front Immunol 2018;9:2853

Date

12/24/2018

Pubmed ID

30574143

Pubmed Central ID

PMC6291446

DOI

10.3389/fimmu.2018.02853

Scopus ID

2-s2.0-85058870758 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

Graft-vs.-host disease (GVHD) remains a major obstacle to the success of allogeneic hematopoietic stem cell transplantation (HSCT). GVHD occurs because donor T cells in the allograft recognize the genetically disparate host as foreign and attack the transplant recipient's tissues. While genetic incompatibility between donor and recipient is the primary determinant for the extent of alloimmune response, GVHD incidence and severity are also influenced by non-genetic factors. Recent advances in immunology establish that environmental factors, including dietary micronutrients, contribute significantly to modulating various immune responses and may influence the susceptibility to autoimmune and inflammatory diseases of experimental animals and humans. Emerging clinical and preclinical evidence indicates that certain micronutrients may participate in regulating GVHD risk after allogeneic HSCT. In this review, we summarize recent advances in our understanding with respect to the potential role of micronutrients in the pathogenesis of acute and chronic GVHD, focusing on vitamins A and D.

Author List

Chen X, Mayne CG

Author

Xiao Chen PhD, MD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Cell Movement
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Incidence
Micronutrients
Nutritional Status
Severity of Illness Index
T-Lymphocytes
Transplantation, Homologous
Vitamin A
Vitamin D