BSS Plus: a potential irrigating solution for neurosurgery. J Neurosurg 1986 Jun;64(6):911-7
Date
06/01/1986Pubmed ID
3701442DOI
10.3171/jns.1986.64.6.0911Scopus ID
2-s2.0-0022536718 (requires institutional sign-in at Scopus site)Abstract
BSS Plus is a pH-stable balanced salt solution similar to glutathione bicarbonate Ringer's solution. Extensively used in ophthalmology, it is of potential value in neurosurgery. In comparative tests of its effectiveness, 28 cats underwent bilateral irrigation of the surface of the cerebral cortex with normal saline on one side and BSS Plus on the other. After 2 hours, a marked decrease was seen in the surface pH of the hemisphere irrigated with normal saline but not of the hemisphere treated with BSS Plus. Blood-brain barrier changes (measured with Evans blue dye techniques) were more evident following saline irrigation. Somatosensory evoked potentials and cerebral blood flow were not significantly altered. Conventional light microscopy using three standard stains did not reveal a significant difference. Transmission electron microscopy studies were performed in 14 animals and scanning electron microscopy in six. In five animals both transmission and scanning electron microscopy studies were conducted after irrigation with both agents without a cottonoid cover and with immediate harvest of superficial layers from the living brain and immersion-fixation in glutaraldehyde. Tissue preservation was superior on the BSS Plus side in all studies. This agent may represent an improved irrigation solution for neurosurgery, but further studies are required.
Author List
Meyer GA, Maiman DJ, Edelhauser HF, Lorenzetti OJ, Garancis JMESH terms used to index this publication - Major topics in bold
AnimalsBicarbonates
Cats
Cerebral Cortex
Drug Combinations
Glutathione
Neurosurgery
Sodium Chloride
Therapeutic Irrigation