Nicotinic acetylcholine binding sites in Alzheimer's disease. Brain Res 1986 Apr 16;371(1):146-51
Date
04/16/1986Pubmed ID
3708340DOI
10.1016/0006-8993(86)90819-xScopus ID
2-s2.0-0022457840 (requires institutional sign-in at Scopus site) 418 CitationsAbstract
In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD.
Author List
Whitehouse PJ, Martino AM, Antuono PG, Lowenstein PR, Coyle JT, Price DL, Kellar KJAuthor
Piero G. Antuono MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AcetylcholineAged
Alzheimer Disease
Cerebral Cortex
Choline O-Acetyltransferase
Humans
Nicotine
Receptors, Nicotinic