Topical fluorouracil. II. Postoperative administration in an animal model of glaucoma filtering surgery. Arch Ophthalmol 1986 Jan;104(1):132-6
Date
01/01/1986Pubmed ID
3942536DOI
10.1001/archopht.1986.01050130146041Scopus ID
2-s2.0-0022645070 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
Unilateral posterior lip sclerectomies were performed in ten owl monkeys. Five milligrams of fluorouracil was injected subconjunctivally in each operated eye immediately after surgery. Three drops (approximately 2.4 mg/drop) of fluorouracil were instilled ten minutes apart in each operated eye twice daily on postoperative days 1 through 7 and once daily on postoperative days 8 through 15, 17, 19, and 21. One monkey died on the seventh postoperative day; its death could not be attributed to systemic fluorouracil toxicity. All of the operated eyes had filtering blebs after the full course of fluorouracil, but seven also had corneal epithelial defects. By the seventh postoperative week, two of the operated eyes manifested moderately severe corneal opacification. Ten weeks postoperatively, the electroretinographic a- and b-wave amplitudes averaged 17% and 12% less, respectively, in the seven operated eyes without clinically significant corneal opacification than in the unoperated fellow eyes. Only two eyes had blebs after the 12th postoperative week. Histopathologic examination was performed on five eyes, of which only two revealed patent sclerostomies. Although topical fluorouracil appears to delay bleb scarring, the corneal findings suggest that it may be more toxic than subconjunctival fluorouracil.
Author List
Heuer DK, Gressel MG, Parrish RK 2nd, Folberg R, Dillberger JE, Altman NHAuthor
Dale Heuer MD Emeritus Professor in the Ophthalmology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Administration, TopicalAnimals
Aotus trivirgatus
Electroretinography
Eye
Fluorouracil
Glaucoma
Postoperative Care
Sclera
