Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Left ventricular end-diastolic volume from ejection fraction and stroke volume in pigs during IVC occlusion. J Surg Res 2002 Jul;106(1):76-81



Pubmed ID




Scopus ID

2-s2.0-0036375910   3 Citations


BACKGROUND: Real-time measurement of left ventricular end-diastolic volume (LVEDV), combined with left ventricular end-diastolic pressure (LVEDP), would allow continuous measurement of intraoperative diastolic function. In pursuit of this goal, we examined stroke volume divided by ejection fraction for calculation of LVEDV(sv/ef).

METHODS: Five anesthetized pigs underwent median sternotomy and pericardiotomy. A transit-time ultrasonic flow probe on the ascending aorta provided cardiac output. A micromanometer provided LV end-diastolic pressure. End-diastolic and end-systolic areas were measured from LV short-axis cross sections to obtain ejection fraction. LVEDV(sv/ef) was calculated during IVC occlusion. Steady-state LVEDV(echo) was determined using a three-plane echocardiography model. LVEDV(echo) was used to validate steady-state LVEDA in each experiment.

RESULTS: Correlation coefficients for linear and pressure-volume relation analyses ranged from 0.46 to 0.99. The two methods for measuring LVEDV generated compliance curves with an overall reliability coefficient of 0.84.

CONCLUSIONS: The LVEDV(sv/ef) method may facilitate real-time determination of LV compliance.

Author List

Gallup CJ, Cabreriza SE, Hart JP, Walsh R, Weinberg A, Spotnitz HM


Joseph Hart MD Associate Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Diagnostic Techniques, Cardiovascular
Linear Models
Reproducibility of Results
Stroke Volume
Vena Cava, Inferior