Medical College of Wisconsin
CTSIResearch InformaticsREDCap

Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham Heart Study. Hypertension 2006 May;47(5):861-7

Date

04/06/2006

Pubmed ID

16585411

DOI

10.1161/01.HYP.0000217141.20163.23

Scopus ID

2-s2.0-33646123080 (requires institutional sign-in at Scopus site)   113 Citations

Abstract

Prolonged electrocardiographic QRS duration is frequently observed in congestive heart failure (CHF) patients. We hypothesized that CHF risk increases with longer QRS interval in individuals free of CHF. We evaluated 1759 Framingham Study participants (mean age, 69 years; 63% women) without prior myocardial infarction or CHF who attended a routine examination. QRS duration was analyzed as a continuous (log-transformed) and a categorical variable [referent, <100 ms; incomplete bundle branch block (BBB), 100 to 119 ms; complete BBB, > or =120 ms]. During follow-up (mean, 12.7 years), 324 participants (205 women) developed CHF. CHF incidence increased across the 3 baseline QRS duration categories in both sexes. Each SD increment in log-QRS duration was associated with a multivariable-adjusted 23% increase in CHF risk [95% confidence interval [CI] 8% to 38%; P<0.001]. In time- dependent models with QRS category and risk factors updated every 2 years, incomplete BBB was associated with a 1.4-fold (95% CI, 1.05 to 1.96; P=0.03) and complete BBB with a 1.7-fold (95% CI, 1.28 to 2.35; P<0.001) risk of CHF. These associations were maintained on adjustment for baseline left ventricular mass. In our community-based sample, longer electrocardiographic QRS was associated with increased CHF risk, consistent with the hypothesis that depolarization delay may increase CHF risk.

Author List

Dhingra R, Pencina MJ, Wang TJ, Nam BH, Benjamin EJ, Levy D, Larson MG, Kannel WB, D'Agostino RB Sr, Vasan RS

Author

Ravi Dhingra MBBS Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aged
Bundle-Branch Block
Electrocardiography
Female
Follow-Up Studies
Heart
Heart Failure
Humans
Incidence
Male
Middle Aged
Models, Cardiovascular
Risk Factors