Mechanical properties of OI type III bone tissue measured by nanoindentation. J Biomed Mater Res A 2006 Oct;79(1):71-7
Date
06/08/2006Pubmed ID
16758461DOI
10.1002/jbm.a.30713Scopus ID
2-s2.0-33749027203 (requires institutional sign-in at Scopus site) 43 CitationsAbstract
Nanoindentation was used to characterize the intrinsic mechanical properties of bone tissue from eight (8) children with type III Osteogenesis Imperfecta (OI). The bone samples were harvested from the cortex portion at the site of bowing (the mid 2/3 of the shaft of the tibia/femur). Unlike normal bone tissue, OI type III cortical bone exhibited more isotropic material properties. Young's modulus and hardness values measured in the longitudinal direction did not show significant differences from the transverse measurements. No differences were observed in modulus or hardness in an analysis of the cortical and trabecular samples. The deformation patterns of the OI type III bone during nanoindentation were found to be similar to those of normal adult bone in an analysis of the ratio of modulus to hardness. No correlation was found between nanoindentation measurement and age in an analysis of regression.
Author List
Fan Z, Smith PA, Eckstein EC, Harris GFAuthors
Gerald F. Harris Emeritus Professor in the Orthopaedic Surgery department at Medical College of WisconsinGerald Harris PhD Director in the Orthopaedic Research Engineering Center (OREC) department at Marquette University
MESH terms used to index this publication - Major topics in bold
AnisotropyBone and Bones
Child
Child, Preschool
Hardness
Humans
Nanotechnology
Osteogenesis Imperfecta
