Faculty Collaboration Database

Characterization of proteomic and metabolomic responses to dietary factors and supplements. J Nutr 2007 Dec;137(12):2787-93

Date

11/22/2007

Pubmed ID

18029500

DOI

10.1093/jn/137.12.2787

Scopus ID

2-s2.0-37148999123 (requires institutional sign-in at Scopus site)   36 Citations

Abstract

Over the past decade there has been a renewed interest in research and development of both dietary and nutritional supplements. Significant advancements have been made in the scientific assessment of the quality, safety, and efficacy of these products because of the strong interest in and financial support of these projects. As research in both fields continues to advance, opportunities to use new and innovative research technologies and methodologies, such as proteomics and metabolomics, are critical for the future progress of the science. The purpose of the symposium was to begin the process of communicating new innovative proteomic and metabolomic methodologies that may be applied by researchers in both the nutrition and the natural product communities. This symposium highlighted 2 proteomic approaches, protein fingerprinting in complex mixtures with peptoid microarrays and top-down mass spectrometry for annotation of gene products. Likewise, an overview of the methodologies used in metabolomic profiling of natural products was presented, and an illustration of an integrated metabolomics approach in nutrition research was highlighted.

Author List

Astle J, Ferguson JT, German JB, Harrigan GG, Kelleher NL, Kodadek T, Parks BA, Roth MJ, Singletary KW, Wenger CD, Mahady GB

MESH terms used to index this publication - Major topics in bold

Adult
Biological Products
Biomarkers
Diet
Dietary Supplements
Female
Gene Expression Profiling
Gene Expression Regulation
Humans
Male
Nutritional Sciences
Peptide Mapping
Polymorphism, Genetic
Proteomics