| 4 | Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide. (Sapouckey SA, Morselli LL, Deng G, Patil CN, Balapattabi K, Oliveira V, Claflin KE, Gomez J, Pearson NA, Potthoff MJ, Gibson-Corley KN, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2020 May 01;318(5):R855-R869 10 Citations |
| 1 | Smooth Muscle Cell-Specific Disruption of the BBSome Causes Vascular Dysfunction. (Reho JJ, Guo DF, Morgan DA, Rahmouni K) Hypertension 2019 Oct;74(4):817-825 16 Citations |
| 2 | How Is the Brain Renin-Angiotensin System Regulated? (Nakagawa P, Sigmund CD) Hypertension 2017 Jul;70(1):10-18 72 Citations |
| 2 | Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice. (Agassandian K, Grobe JL, Liu X, Agassandian M, Thompson AP, Sigmund CD, Cassell MD) Am J Physiol Regul Integr Comp Physiol 2017 Jun 01;312(6):R973-R981 14 Citations |
| 1 | Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice. (Chu Y, Lund DD, Doshi H, Keen HL, Knudtson KL, Funk ND, Shao JQ, Cheng J, Hajj GP, Zimmerman KA, Davis MK, Brooks RM, Chapleau MW, Sigmund CD, Weiss RM, Heistad DD) Arterioscler Thromb Vasc Biol 2016 Mar;36(3):466-74 21 Citations |
| 2 | Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake. (Coble JP, Cassell MD, Davis DR, Grobe JL, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2014 Aug 15;307(4):R376-86 26 Citations |
| 2 | Allele-specific expression of angiotensinogen in human subcutaneous adipose tissue. (Park S, Lu KT, Liu X, Chatterjee TK, Rudich SM, Weintraub NL, Kwitek AE, Sigmund CD) Hypertension 2013 Jul;62(1):41-7 13 Citations |
| 1 | The adipose/circulating renin-angiotensin system cross-talk enters a new dimension. (Grobe JL, Rahmouni K) Hypertension 2012 Dec;60(6):1389-90 9 Citations |
| 1 | Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression. (Park S, Liu X, Davis DR, Sigmund CD) Hypertension 2012 Jun;59(6):1212-9 12 Citations |
| 1 | Editorial focus: A fat contribution to RAS activation and blood pressure control: evidence from angiotensinogen conditional null mice. Focus on: "Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice.". (Grobe JL, Rahmouni K) Am J Physiol Regul Integr Comp Physiol 2012 Jan 15;302(2):R242-3 |
| 1 | Structural biology: On stress and pressure. (Sigmund CD) Nature 2010 Nov 04;468(7320):46-7 7 Citations |
| 2 | The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. (Grobe JL, Grobe CL, Beltz TG, Westphal SG, Morgan DA, Xu D, de Lange WJ, Li H, Sakai K, Thedens DR, Cassis LA, Rahmouni K, Mark AL, Johnson AK, Sigmund CD) Cell Metab 2010 Nov 03;12(5):431-42 141 Citations |
| 2 | Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice. (Grobe JL, Dickson ME, Park S, Davis DR, Born EJ, Sigmund CD) Hypertension 2010 Nov;56(5):981-7 9 Citations |
| 1 | Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice. (Chen S, Li G, Zhang W, Wang J, Sigmund CD, Olson JE, Chen Y) Am J Physiol Regul Integr Comp Physiol 2009 Nov;297(5):R1526-31 40 Citations |
| 1 | A growing chain of evidence linking genetic variation in angiotensinogen with essential hypertension: focus on "a haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G," by Jain et al. (Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2008 Dec;295(6):R1846-8 1 Citation |
| 1 | Upstream stimulatory factor is required for human angiotensinogen expression and differential regulation by the A-20C polymorphism. (Dickson ME, Tian X, Liu X, Davis DR, Sigmund CD) Circ Res 2008 Oct 24;103(9):940-7 17 Citations |
| 1 | Renal regional proteomes in young Dahl salt-sensitive rats. (Tian Z, Greene AS, Usa K, Matus IR, Bauwens J, Pietrusz JL, Cowley AW Jr, Liang M) Hypertension 2008 Apr;51(4):899-904 56 Citations |
| 1 | Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice. (Kobori H, Ozawa Y, Satou R, Katsurada A, Miyata K, Ohashi N, Hase N, Suzaki Y, Sigmund CD, Navar LG) Am J Physiol Renal Physiol 2007 Sep;293(3):F938-45 90 Citations |
| 1 | The -20 and -217 promoter variants dominate differential angiotensinogen haplotype regulation in angiotensinogen-expressing cells. (Dickson ME, Zimmerman MB, Rahmouni K, Sigmund CD) Hypertension 2007 Mar;49(3):631-9 34 Citations |
| 1 | Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response. (Sinnayah P, Lazartigues E, Sakai K, Sharma RV, Sigmund CD, Davisson RL) Circ Res 2006 Nov 10;99(10):1125-31 40 Citations |
| 1 | Genetic basis of hypertension: revisiting angiotensinogen. (Dickson ME, Sigmund CD) Hypertension 2006 Jul;48(1):14-20 121 Citations |
| 1 | Angiotensinogen modulates renal vasculature growth. (Brand M, Lamandé N, Sigmund CD, Larger E, Corvol P, Gasc JM) Hypertension 2006 Jun;47(6):1067-74 16 Citations |
| 1 | RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. (Sachetelli S, Liu Q, Zhang SL, Liu F, Hsieh TJ, Brezniceanu ML, Guo DF, Filep JG, Ingelfinger JR, Sigmund CD, Hamet P, Chan JS) Kidney Int 2006 Mar;69(6):1016-23 115 Citations |
| 1 | Evidence supporting a functional role for intracellular renin in the brain. (Lavoie JL, Liu X, Bianco RA, Beltz TG, Johnson AK, Sigmund CD) Hypertension 2006 Mar;47(3):461-6 68 Citations |
| 1 | Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice. (Sherrod M, Davis DR, Zhou X, Cassell MD, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2005 Dec;289(6):R1763-9 31 Citations |
| 1 | Cerebral vascular effects of angiotensin II: new insights from genetic models. (Faraci FM, Lamping KG, Modrick ML, Ryan MJ, Sigmund CD, Didion SP) J Cereb Blood Flow Metab 2006 Apr;26(4):449-55 89 Citations |
| 1 | Spontaneous stroke in a genetic model of hypertension in mice. (Iida S, Baumbach GL, Lavoie JL, Faraci FM, Sigmund CD, Heistad DD) Stroke 2005 Jun;36(6):1253-8 55 Citations |
| 1 | Effects of cortisol on cardiac myocytes and on expression of cardiac genes in fetal sheep. (Lumbers ER, Boyce AC, Joulianos G, Kumarasamy V, Barner E, Segar JL, Burrell JH) Am J Physiol Regul Integr Comp Physiol 2005 Mar;288(3):R567-74 76 Citations |
| 1 | Differential modulation of baroreflex control of heart rate by neuron- vs. glia-derived angiotensin II. (Sakai K, Chapleau MW, Morimoto S, Cassell MD, Sigmund CD) Physiol Genomics 2004 Dec 15;20(1):66-72 33 Citations |
| 1 | Nuclear localization of angiotensinogen in astrocytes. (Sherrod M, Liu X, Zhang X, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2005 Feb;288(2):R539-46 59 Citations |
| 1 | Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule. (Lavoie JL, Lake-Bruse KD, Sigmund CD) Am J Physiol Renal Physiol 2004 May;286(5):F965-71 103 Citations |
| 1 | Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model. (Lavoie JL, Cassell MD, Gross KW, Sigmund CD) Hypertension 2004 May;43(5):1116-9 78 Citations |
| 1 | Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity. (Rahmouni K, Mark AL, Haynes WG, Sigmund CD) Am J Physiol Endocrinol Metab 2004 Jun;286(6):E891-5 105 Citations |
| 1 | PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. (Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD) Hypertension 2004 Mar;43(3):661-6 179 Citations |
| 1 | Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice. (Ma X, Sigmund CD, Hingtgen SD, Tian X, Davisson RL, Abboud FM, Chapleau MW) Hypertension 2004 Feb;43(2):312-6 27 Citations |
| 1 | Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen. (Baumbach GL, Sigmund CD, Faraci FM) Hypertension 2003 Jan;41(1):50-5 91 Citations |
| 1 | Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse. (Cvetkovic B, Keen HL, Zhang X, Davis D, Yang B, Sigmund CD) Physiol Genomics 2002 Dec 03;11(3):253-62 25 Citations |
| 1 | Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen. (Didion SP, Ryan MJ, Baumbach GL, Sigmund CD, Faraci FM) Am J Physiol Heart Circ Physiol 2002 Oct;283(4):H1569-76 60 Citations |
| 1 | Neuron-specific expression of human angiotensinogen in brain causes increased salt appetite. (Morimoto S, Cassell MD, Sigmund CD) Physiol Genomics 2002;9(2):113-20 37 Citations |
| 1 | Lower blood pressure in floxed angiotensinogen mice after adenoviral delivery of Cre-recombinase. (Stec DE, Keen HL, Sigmund CD) Hypertension 2002 Feb;39(2 Pt 2):629-33 25 Citations |
| 1 | The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene. (Morimoto S, Cassell MD, Sigmund CD) Circ Res 2002 Jan 11;90(1):80-6 44 Citations |
| 1 | Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter. (Morimoto S, Cassell MD, Beltz TG, Johnson AK, Davisson RL, Sigmund CD) Circ Res 2001 Aug 17;89(4):365-72 100 Citations |
| 1 | Paradoxical regulation of short promoter human renin transgene by angiotensin ii. (Keen HL, Sigmund CD) Hypertension 2001 Feb;37(2 Pt 2):403-7 11 Citations |
| 1 | Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice. (Ding Y, Sigmund CD) Am J Physiol Renal Physiol 2001 Jan;280(1):F54-60 49 Citations |
| 1 | Genetic evidence that lethality in angiotensinogen-deficient mice is due to loss of systemic but not renal angiotensinogen. (Ding Y, Stec DE, Sigmund CD) J Biol Chem 2001 Mar 09;276(10):7431-6 20 Citations |
| 1 | Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. (Davisson RL, Ding Y, Stec DE, Catterall JF, Sigmund CD) Physiol Genomics 1999 Jul 15;1(1):3-9 113 Citations |
| 1 | Transgenic and knockout mice to study the renin-angiotensin system and other interacting vasoactive pathways. (Lake-Bruse KD, Sigmund CD) Curr Hypertens Rep 2000 Apr;2(2):211-6 9 Citations |
| 1 | Impaired endothelial function in transgenic mice expressing both human renin and human angiotensinogen. (Didion SP, Sigmund CD, Faraci FM) Stroke 2000 Mar;31(3):760-4; discussion 765 54 Citations |
| 1 | Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination. (Cvetkovic B, Yang B, Williamson RA, Sigmund CD) J Biol Chem 2000 Jan 14;275(2):1073-8 46 Citations |
| 1 | Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo. (Stec DE, Davisson RL, Haskell RE, Davidson BL, Sigmund CD) J Biol Chem 1999 Jul 23;274(30):21285-90 76 Citations |
| 1 | The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system. (Yang G, Gray TS, Sigmund CD, Cassell MD) Brain Res 1999 Jan 30;817(1-2):123-31 87 Citations |
| 1 | Developmental expression of human angiotensinogen in transgenic mice. (Yang G, Sigmund CD) Am J Physiol 1998 May;274(5):F932-9 13 Citations |
| 1 | Regulatory elements required for human angiotensinogen expression in HepG2 cells are dispensable in transgenic mice. (Yang G, Sigmund CD) Hypertension 1998 Mar;31(3):734-40 21 Citations |
| 1 | The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. (Ding Y, Davisson RL, Hardy DO, Zhu LJ, Merrill DC, Catterall JF, Sigmund CD) J Biol Chem 1997 Oct 31;272(44):28142-8 119 Citations |
| 1 | Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. (Davisson RL, Kim HS, Krege JH, Lager DJ, Smithies O, Sigmund CD) J Clin Invest 1997 Mar 15;99(6):1258-64 67 Citations |
| 1 | Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. (Merrill DC, Thompson MW, Carney CL, Granwehr BP, Schlager G, Robillard JE, Sigmund CD) J Clin Invest 1996 Feb 15;97(4):1047-55 164 Citations |
| 1 | Transgenic animals in the study of blood pressure regulation and hypertension. (Thompson MW, Merrill DC, Yang G, Robillard JE, Sigmund CD) Am J Physiol 1995 Nov;269(5 Pt 1):E793-803 18 Citations |
| 1 | Effect of cortisol on gene expression of the renin-angiotensin system in fetal sheep. (Segar JL, Bedell K, Page WV, Mazursky JE, Nuyt AM, Robillard JE) Pediatr Res 1995 Jun;37(6):741-6 69 Citations |
| 1 | Functional expression of the human angiotensinogen gene in transgenic mice. (Yang G, Merrill DC, Thompson MW, Robillard JE, Sigmund CD) J Biol Chem 1994 Dec 23;269(51):32497-502 116 Citations |
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