| 1 | Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression. (Oleinik NV, Atilgan FC, Kassir MF, Lee HG, Janneh AH, Wofford W, Walton C, Szulc ZM, Hill EG, Alekseyenko AV, Cimen H, Hartman JH, Voelkel-Johnson C, Lilly MB, Lemasters JJ, Frizzell N, Yu XZ, Mehrotra S, Ogretmen B) Cancer Res 2025 Sep 02;85(17):3313-3334 2 Citations |
| 2 | Cardiac dysfunction and altered gene expression in acid ceramidase-deficient mice. (Kleynerman A, Rybova J, McKillop WM, Dlugi TA, Faber ML, Fuller M, O'Meara CC, Medin JA) Am J Physiol Heart Circ Physiol 2025 Jan 01;328(1):H141-H156 3 Citations |
| 1 | Ceramide metabolism alterations contribute to Tumor Necrosis Factor-induced melanoma dedifferentiation and predict resistance to immune checkpoint inhibitors in advanced melanoma patients. (Dufau C, Genais M, Mucher E, Jung B, Garcia V, Montfort A, Tosolini M, Clarke CJ, Medin JA, Levade T, Delord JP, Meyer N, Pancaldi V, Andrieu-Abadie N, Ségui B) Front Immunol 2024;15:1421432 4 Citations |
| 1 | Hematopoietic stem cell transplantation leads to biochemical and functional correction in two mouse models of acid ceramidase deficiency. (Rybova J, Sundararajan T, Kuchar L, Dlugi TA, Ruzicka P, McKillop WM, Medin JA) Mol Ther 2024 Oct 02;32(10):3402-3421 6 Citations |
| 1 | Necessary Role of Ceramides in the Human Microvascular Endothelium During Health and Disease. (SenthilKumar G, Katunaric B, Zirgibel Z, Lindemer B, Jaramillo-Torres MJ, Bordas-Murphy H, Schulz ME, Pearson PJ, Freed JK) Circ Res 2024 Jan 05;134(1):81-96 12 Citations |
| 2 | Acid Ceramidase Deficiency: Bridging Gaps between Clinical Presentation, Mouse Models, and Future Therapeutic Interventions. (Kleynerman A, Rybova J, Faber ML, McKillop WM, Levade T, Medin JA) Biomolecules 2023 Feb 01;13(2) 17 Citations |
| 2 | Skin inflammation and impaired adipogenesis in a mouse model of acid ceramidase deficiency. (Rybova J, Kuchar L, Sikora J, McKillop WM, Medin JA) J Inherit Metab Dis 2022 Nov;45(6):1175-1190 7 Citations |
| 3 | Lipid signatures of chronic pain in female adolescents with and without obesity. (Gonzalez PA, Simcox J, Raff H, Wade G, Von Bank H, Weisman S, Hainsworth K) Lipids Health Dis 2022 Aug 30;21(1):80 11 Citations |
| 2 | rAAV-mediated over-expression of acid ceramidase prevents retinopathy in a mouse model of Farber lipogranulomatosis. (Zhang H, Nagree MS, Liu H, Pan X, Medin JA, Lipinski DM) Gene Ther 2023 Apr;30(3-4):297-308 5 Citations |
| 1 | Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK pathway. (Sofi MH, Tian L, Schutt S, Khan I, Choi HJ, Wu Y, Bastian D, Ticer T, Kassir MF, Atilgan FC, Kim J, Sui X, Zivkovic A, Mehrotra S, O'Bryan JP, Stark H, Martin PJ, Ogretmen B, Yu XZ) Leukemia 2022 Jul;36(7):1907-1915 15 Citations |
| 1 | Epidermal 1-O-acylceramides appear with the establishment of the water permeability barrier in mice and are produced by maturating keratinocytes. (Rabionet M, Bernard P, Pichery M, Marsching C, Bayerle A, Dworski S, Kamani MA, Chitraju C, Gluchowski NL, Gabriel KR, Asadi A, Ebel P, Hoekstra M, Dumas S, Ntambi JM, Jacobsson A, Willecke K, Medin JA, Jonca N, Sandhoff R) Lipids 2022 May;57(3):183-195 7 Citations |
| 1 | Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response. (Vaena S, Chakraborty P, Lee HG, Janneh AH, Kassir MF, Beeson G, Hedley Z, Yalcinkaya A, Sofi MH, Li H, Husby ML, Stahelin RV, Yu XZ, Mehrotra S, Ogretmen B) Cell Rep 2021 May 04;35(5):109076 70 Citations |
| 1 | Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner. (Bayerle A, Marsching C, Rabionet M, Dworski S, Kamani MA, Chitraju C, Gluchowski NL, Gabriel KR, Herzer S, Jennemann R, Levade T, Medin JA, Sandhoff R) Biochim Biophys Acta Mol Cell Biol Lipids 2020 Sep;1865(9):158741 12 Citations |
| 1 | Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress. (Oleinik N, Kim J, Roth BM, Selvam SP, Gooz M, Johnson RH, Lemasters JJ, Ogretmen B) Sci Adv 2019 Sep;5(9):eaax1978 45 Citations |
| 1 | Manipulation of the Sphingolipid Rheostat Influences the Mediator of Flow-Induced Dilation in the Human Microvasculature. (Schulz ME, Katunaric B, Hockenberry JC, Gutterman DD, Freed JK) J Am Heart Assoc 2019 Sep 03;8(17):e013153 7 Citations |
| 2 | Inherited monogenic defects of ceramide metabolism: Molecular bases and diagnoses. (Dubot P, Sabourdy F, Rybova J, Medin JA, Levade T) Clin Chim Acta 2019 Aug;495:457-466 3 Citations |
| 3 | Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment. (Yu FPS, Sajdak BS, Sikora J, Salmon AE, Nagree MS, Gurka J, Kassem IS, Lipinski DM, Carroll J, Medin JA) Am J Pathol 2019 Feb;189(2):320-338 19 Citations |
| 1 | Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency. (Yu FPS, Islam D, Sikora J, Dworski S, Gurka J, López-Vásquez L, Liu M, Kuebler WM, Levade T, Zhang H, Medin JA) Am J Physiol Lung Cell Mol Physiol 2018 Mar 01;314(3):L406-L420 30 Citations |
| 1 | Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy. (Dworski S, Lu P, Khan A, Maranda B, Mitchell JJ, Parini R, Di Rocco M, Hugle B, Yoshimitsu M, Magnusson B, Makay B, Arslan N, Guelbert N, Ehlert K, Jarisch A, Gardner-Medwin J, Dagher R, Terreri MT, Lorenco CM, Barillas-Arias L, Tanpaiboon P, Solyom A, Norris JS, He X, Schuchman EH, Levade T, Medin JA) Biochim Biophys Acta Mol Basis Dis 2017 Feb;1863(2):386-394 38 Citations |
| 1 | On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. (Jones EE, Dworski S, Canals D, Casas J, Fabrias G, Schoenling D, Levade T, Denlinger C, Hannun YA, Medin JA, Drake RR) Anal Chem 2014 Aug 19;86(16):8303-11 67 Citations |
| 1 | Systemic ceramide accumulation leads to severe and varied pathological consequences. (Alayoubi AM, Wang JC, Au BC, Carpentier S, Garcia V, Dworski S, El-Ghamrasni S, Kirouac KN, Exertier MJ, Xiong ZJ, Privé GG, Simonaro CM, Casas J, Fabrias G, Schuchman EH, Turner PV, Hakem R, Levade T, Medin JA) EMBO Mol Med 2013 Jun;5(6):827-42 103 Citations |
| 1 | Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers. (Sorci-Thomas MG, Owen JS, Fulp B, Bhat S, Zhu X, Parks JS, Shah D, Jerome WG, Gerelus M, Zabalawi M, Thomas MJ) J Lipid Res 2012 Sep;53(9):1890-909 106 Citations |
| 1 | A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death. (Baldwin AC, Green CD, Olson LK, Moxley MA, Corbett JA) Am J Physiol Endocrinol Metab 2012 Jun 01;302(11):E1390-8 63 Citations |
| 1 | Acid sphingomyelinase deficiency does not protect from graft-versus-host disease in transplant recipients with Niemann-Pick disease. (Tolar J, Eapen M, Orchard PJ, Blazar BR) Blood 2010 Jan 14;115(2):434-5 3 Citations |
| 1 | In vivo delivery of human acid ceramidase via cord blood transplantation and direct injection of lentivirus as novel treatment approaches for Farber disease. (Ramsubir S, Nonaka T, Girbés CB, Carpentier S, Levade T, Medin JA) Mol Genet Metab 2008 Nov;95(3):133-41 32 Citations |
| 1 | Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes. (Prasad VV, Nithipatikom K, Harder DR) Neurochem Int 2008 Dec;53(6-8):220-9 31 Citations |
| 2 | Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence. (Zhao H, Joseph J, Fales HM, Sokoloski EA, Levine RL, Vasquez-Vivar J, Kalyanaraman B) Proc Natl Acad Sci U S A 2005 Apr 19;102(16):5727-32 527 Citations |
| 1 | Endostatin uncouples NO and Ca2+ response to bradykinin through enhanced O2*- production in the intact coronary endothelium. (Zhang AY, Teggatz EG, Zou AP, Campbell WB, Li PL) Am J Physiol Heart Circ Physiol 2005 Feb;288(2):H686-94 31 Citations |
| 1 | Ceramide-induced intracellular oxidant formation, iron signaling, and apoptosis in endothelial cells: protective role of endogenous nitric oxide. (Matsunaga T, Kotamraju S, Kalivendi SV, Dhanasekaran A, Joseph J, Kalyanaraman B) J Biol Chem 2004 Jul 02;279(27):28614-24 96 Citations |
| 1 | The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs. (Veldman RJ, Mita A, Cuvillier O, Garcia V, Klappe K, Medin JA, Campbell JD, Carpentier S, Kok JW, Levade T) FASEB J 2003 Jun;17(9):1144-6 40 Citations |
| 1 | Ceramide-induced activation of NADPH oxidase and endothelial dysfunction in small coronary arteries. (Zhang DX, Zou AP, Li PL) Am J Physiol Heart Circ Physiol 2003 Feb;284(2):H605-12 113 Citations |
| 1 | Role of ceramide in TNF-alpha-induced impairment of endothelium-dependent vasorelaxation in coronary arteries. (Zhang DX, Yi FX, Zou AP, Li PL) Am J Physiol Heart Circ Physiol 2002 Nov;283(5):H1785-94 67 Citations |
| 2 | Production and metabolism of ceramide in normal and ischemic-reperfused myocardium of rats. (Zhang DX, Fryer RM, Hsu AK, Zou AP, Gross GJ, Campbell WB, Li PL) Basic Res Cardiol 2001;96(3):267-74 80 Citations |
| 1 | Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries. (Zhang DX, Zou AP, Li PL) Circ Res 2001 Apr 27;88(8):824-31 73 Citations |
| 1 | Stress-induced apoptosis is not mediated by endolysosomal ceramide. (Ségui B, Bezombes C, Uro-Coste E, Medin JA, Andrieu-Abadie N, Augé N, Brouchet A, Laurent G, Salvayre R, Jaffrézou JP, Levade T) FASEB J 2000 Jan;14(1):36-47 51 Citations |
| 1 | Ceramide signalling and the immune response. (Ballou LR, Laulederkind SJ, Rosloniec EF, Raghow R) Biochim Biophys Acta 1996 Jun 11;1301(3):273-87 253 Citations |
| 1 | Characterization of the sphingomyelin content of isolated pancreatic islets. Evaluation of the role of sphingomyelin hydrolysis in the action of interleukin-1 to induce islet overproduction of nitric oxide. (Kwon G, Bohrer A, Han X, Corbett JA, Ma Z, Gross RW, McDaniel ML, Turk J) Biochim Biophys Acta 1996 Mar 29;1300(1):63-72 24 Citations |
| 1 | Ceramide induces interleukin 6 gene expression in human fibroblasts. (Laulederkind SJ, Bielawska A, Raghow R, Hannun YA, Ballou LR) J Exp Med 1995 Aug 01;182(2):599-604 79 Citations |
