1 | Renal release of N-acetyl-seryl-aspartyl-lysyl-proline is part of an antifibrotic peptidergic system in the kidney. (Romero CA, Kumar N, Nakagawa P, Worou ME, Liao TD, Peterson EL, Carretero OA) Am J Physiol Renal Physiol 2019 Jan 01;316(1):F195-F203 16 Citations |
3 | Transcriptomic analysis reveals inflammatory and metabolic pathways that are regulated by renal perfusion pressure in the outer medulla of Dahl-S rats. (Evans LC, Dayton A, Yang C, Liu P, Kurth T, Ahn KW, Komas S, Stingo FC, Laud PW, Vannucci M, Liang M, Cowley AW Jr) Physiol Genomics 2018 Jun 01;50(6):440-447 10 Citations |
1 | Collecting Duct Renin Does Not Mediate DOCA-Salt Hypertension or Renal Injury. (Song K, Stuart D, Abraham N, Wang F, Wang S, Yang T, Sigmund CD, Kohan DE, Ramkumar N) PLoS One 2016;11(7):e0159872 12 Citations |
1 | Null mutation of the nicotinamide adenine dinucleotide phosphate-oxidase subunit p67phox protects the Dahl-S rat from salt-induced reductions in medullary blood flow and glomerular filtration rate. (Evans LC, Ryan RP, Broadway E, Skelton MM, Kurth T, Cowley AW Jr) Hypertension 2015 Mar;65(3):561-8 27 Citations |
1 | Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension. (Cowley AW Jr, Abe M, Mori T, O'Connor PM, Ohsaki Y, Zheleznova NN) Am J Physiol Renal Physiol 2015 Feb 01;308(3):F179-97 86 Citations |
1 | Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence. (Liu Y, Liu P, Yang C, Cowley AW Jr, Liang M) Hypertension 2014 Apr;63(4):827-38 61 Citations |
1 | Real-time electrochemical detection of ATP and H₂O₂ release in freshly isolated kidneys. (Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Ryan RP, Cowley AW Jr, Staruschenko A) Am J Physiol Renal Physiol 2013 Jul 01;305(1):F134-41 32 Citations |
1 | Medullary thick ascending limb buffer vasoconstriction of renal outer-medullary vasa recta in salt-resistant but not salt-sensitive rats. (O'Connor PM, Cowley AW Jr) Hypertension 2012 Oct;60(4):965-72 18 Citations |
2 | Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. (Feng D, Yang C, Geurts AM, Kurth T, Liang M, Lazar J, Mattson DL, O'Connor PM, Cowley AW Jr) Cell Metab 2012 Feb 08;15(2):201-8 116 Citations |
1 | Role of medullary blood flow in the pathogenesis of renal ischemia-reperfusion injury. (Regner KR, Roman RJ) Curr Opin Nephrol Hypertens 2012 Jan;21(1):33-8 66 Citations |
1 | Increase of sodium delivery stimulates the mitochondrial respiratory chain H2O2 production in rat renal medullary thick ascending limb. (Ohsaki Y, O'Connor P, Mori T, Ryan RP, Dickinson BC, Chang CJ, Lu Y, Ito S, Cowley AW Jr) Am J Physiol Renal Physiol 2012 Jan 01;302(1):F95-F102 42 Citations |
1 | Modulation of pressure-natriuresis by renal medullary reactive oxygen species and nitric oxide. (O'Connor PM, Cowley AW Jr) Curr Hypertens Rep 2010 Apr;12(2):86-92 53 Citations |
1 | Role of renal perfusion pressure versus angiotensin II on renal oxidative stress in angiotensin II-induced hypertensive rats. (Polichnowski AJ, Jin C, Yang C, Cowley AW Jr) Hypertension 2010 Jun;55(6):1425-30 29 Citations |
1 | Renal medullary microRNAs in Dahl salt-sensitive rats: miR-29b regulates several collagens and related genes. (Liu Y, Taylor NE, Lu L, Usa K, Cowley AW Jr, Ferreri NR, Yeo NC, Liang M) Hypertension 2010 Apr;55(4):974-82 219 Citations |
1 | Novel role of fumarate metabolism in dahl-salt sensitive hypertension. (Tian Z, Liu Y, Usa K, Mladinov D, Fang Y, Ding X, Greene AS, Cowley AW Jr, Liang M) Hypertension 2009 Aug;54(2):255-60 59 Citations |
1 | Effects of renal perfusion pressure on renal medullary hydrogen peroxide and nitric oxide production. (Jin C, Hu C, Polichnowski A, Mori T, Skelton M, Ito S, Cowley AW Jr) Hypertension 2009 Jun;53(6):1048-53 45 Citations |
2 | Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury. (Regner KR, Zuk A, Van Why SK, Shames BD, Ryan RP, Falck JR, Manthati VL, McMullen ME, Ledbetter SR, Roman RJ) Kidney Int 2009 Mar;75(5):511-7 74 Citations |
1 | Renal medullary oxidative stress, pressure-natriuresis, and hypertension. (Cowley AW Jr) Hypertension 2008 Nov;52(5):777-86 126 Citations |
1 | Enhanced amiloride-sensitive superoxide production in renal medullary thick ascending limb of Dahl salt-sensitive rats. (O'Connor PM, Lu L, Schreck C, Cowley AW Jr) Am J Physiol Renal Physiol 2008 Sep;295(3):F726-33 19 Citations |
1 | Vasopressin-induced nitric oxide production in rat inner medullary collecting duct is dependent on V2 receptor activation of the phosphoinositide pathway. (O'Connor PM, Cowley AW Jr) Am J Physiol Renal Physiol 2007 Aug;293(2):F526-32 24 Citations |
1 | Enhanced superoxide production in renal outer medulla of Dahl salt-sensitive rats reduces nitric oxide tubular-vascular cross-talk. (Mori T, O'Connor PM, Abe M, Cowley AW Jr) Hypertension 2007 Jun;49(6):1336-41 72 Citations |
1 | Renal interstitial corticosterone and 11-dehydrocorticosterone in conscious rats. (Usa K, Singh RJ, Netzel BC, Liu Y, Raff H, Liang M) Am J Physiol Renal Physiol 2007 Jul;293(1):F186-92 22 Citations |
1 | NO synthase uncoupling in the kidney of Dahl S rats: role of dihydrobiopterin. (Taylor NE, Maier KG, Roman RJ, Cowley AW Jr) Hypertension 2006 Dec;48(6):1066-71 46 Citations |
1 | Effect of sodium delivery on superoxide and nitric oxide in the medullary thick ascending limb. (Abe M, O'Connor P, Kaldunski M, Liang M, Roman RJ, Cowley AW Jr) Am J Physiol Renal Physiol 2006 Aug;291(2):F350-7 61 Citations |
1 | NADPH oxidase in the renal medulla causes oxidative stress and contributes to salt-sensitive hypertension in Dahl S rats. (Taylor NE, Glocka P, Liang M, Cowley AW Jr) Hypertension 2006 Apr;47(4):692-8 166 Citations |
1 | Molecular mechanisms and therapeutic strategies of chronic renal injury: physiological role of angiotensin II-induced oxidative stress in renal medulla. (Mori T, Cowley AW Jr, Ito S) J Pharmacol Sci 2006 Jan;100(1):2-8 46 Citations |
1 | Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. (Roman RJ, Hoagland KM, Lopez B, Kwitek AE, Garrett MR, Rapp JP, Lazar J, Jacob HJ, Sarkis A) Am J Physiol Renal Physiol 2006 Jun;290(6):F1463-71 27 Citations |
1 | Effect of renal medullary H2O2 on salt-induced hypertension and renal injury. (Taylor NE, Cowley AW Jr) Am J Physiol Regul Integr Comp Physiol 2005 Dec;289(6):R1573-9 84 Citations |
1 | Nephrolithiasis and nephrocalcinosis in rats with small bowel resection. (O'Connor RC, Worcester EM, Evan AP, Meehan S, Kuznetsov D, Laven B, Sommer AJ, Bledsoe SB, Parks JH, Coe FL, Grynpas M, Gerber GS) Urol Res 2005 May;33(2):105-15 25 Citations |
1 | Renal oxidative stress in medullary thick ascending limbs produced by elevated NaCl and glucose. (Mori T, Cowley AW Jr) Hypertension 2004 Feb;43(2):341-6 70 Citations |
1 | Reactive oxygen species and molecular regulation of renal oxygenation. (Zou AP, Cowley AW Jr) Acta Physiol Scand 2003 Nov;179(3):233-41 70 Citations |
1 | Angiotensin II-NAD(P)H oxidase-stimulated superoxide modifies tubulovascular nitric oxide cross-talk in renal outer medulla. (Mori T, Cowley AW Jr) Hypertension 2003 Oct;42(4):588-93 89 Citations |
1 | Increased H(2)O(2) counteracts the vasodilator and natriuretic effects of superoxide dismutation by tempol in renal medulla. (Chen YF, Cowley AW Jr, Zou AP) Am J Physiol Regul Integr Comp Physiol 2003 Oct;285(4):R827-33 111 Citations |
1 | Increased renal medullary H2O2 leads to hypertension. (Makino A, Skelton MM, Zou AP, Cowley AW Jr) Hypertension 2003 Jul;42(1):25-30 123 Citations |
1 | Role of renal NO production in the regulation of medullary blood flow. (Cowley AW Jr, Mori T, Mattson D, Zou AP) Am J Physiol Regul Integr Comp Physiol 2003 Jun;284(6):R1355-69 187 Citations |
1 | Gene expression reveals vulnerability to oxidative stress and interstitial fibrosis of renal outer medulla to nonhypertensive elevations of ANG II. (Yuan B, Liang M, Yang Z, Rute E, Taylor N, Olivier M, Cowley AW Jr) Am J Physiol Regul Integr Comp Physiol 2003 May;284(5):R1219-30 26 Citations |
1 | Countercurrent exchange in the renal medulla. (Cowley AW Jr, Roman RR) Am J Physiol Regul Integr Comp Physiol 2003 May;284(5):R1151 11 Citations |
1 | Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression. (Liang M, Yuan B, Rute E, Greene AS, Olivier M, Cowley AW Jr) Physiol Genomics 2003 Feb 06;12(3):229-37 54 Citations |
1 | Tubulovascular nitric oxide crosstalk: buffering of angiotensin II-induced medullary vasoconstriction. (Dickhout JG, Mori T, Cowley AW Jr) Circ Res 2002 Sep 20;91(6):487-93 97 Citations |
1 | Renal medullary nitric oxide deficit of Dahl S rats enhances hypertensive actions of angiotensin II. (Szentiványi M Jr, Zou AP, Mattson DL, Soares P, Moreno C, Roman RJ, Cowley AW Jr) Am J Physiol Regul Integr Comp Physiol 2002 Jul;283(1):R266-72 70 Citations |
1 | Vasopressin increases intracellular NO concentration via Ca(2+) signaling in inner medullary collecting duct. (Mori T, Dickhout JG, Cowley AW Jr) Hypertension 2002 Feb;39(2 Pt 2):465-9 29 Citations |
1 | Increased renal medullary oxidative stress produces hypertension. (Makino A, Skelton MM, Zou AP, Roman RJ, Cowley AW Jr) Hypertension 2002 Feb;39(2 Pt 2):667-72 150 Citations |
1 | Renal medullary genes in salt-sensitive hypertension: a chromosomal substitution and cDNA microarray study. (Liang M, Yuan B, Rute E, Greene AS, Zou AP, Soares P, MCQuestion GD, Slocum GR, Jacob HJ, Cowley AW Jr) Physiol Genomics 2002 Feb 28;8(2):139-49 47 Citations |
1 | Oxygen-dependent expression of hypoxia-inducible factor-1alpha in renal medullary cells of rats. (Zou AP, Yang ZZ, Li PL, Cowley AW JR) Physiol Genomics 2001 Aug 28;6(3):159-68 50 Citations |
1 | Bradykinin B2 receptors activate Na+/H+ exchange in mIMCD-3 cells via Janus kinase 2 and Ca2+/calmodulin. (Mukhin YV, Vlasova T, Jaffa AA, Collinsworth G, Bell JL, Tholanikunnel BG, Pettus T, Fitzgibbon W, Ploth DW, Raymond JR, Garnovskaya MN) J Biol Chem 2001 May 18;276(20):17339-46 26 Citations |
1 | Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat. (Cowley AW Jr, Roman RJ, Kaldunski ML, Dumas P, Dickhout JG, Greene AS, Jacob HJ) Hypertension 2001 Feb;37(2 Pt 2):456-61 176 Citations |
1 | Production and actions of superoxide in the renal medulla. (Zou AP, Li N, Cowley AW Jr) Hypertension 2001 Feb;37(2 Pt 2):547-53 274 Citations |
1 | Evidence that reduced renal medullary nitric oxide synthase activity of dahl s rats enables small elevations of arginine vasopressin to produce sustained hypertension. (Yuan B, Cowley AW Jr) Hypertension 2001 Feb;37(2 Pt 2):524-8 36 Citations |
1 | alpha(2)-adrenergic receptor-mediated increase in NO production buffers renal medullary vasoconstriction. (Zou AP, Cowley AW Jr) Am J Physiol Regul Integr Comp Physiol 2000 Sep;279(3):R769-77 68 Citations |
1 | Control of the renal medullary circulation by vasopressin V1 and V2 receptors in the rat. (Cowley AW Jr) Exp Physiol 2000 Mar;85 Spec No:223S-231S 49 Citations |
1 | Nitric oxide in the renal medulla protects from vasopressin-induced hypertension. (Szentiványi M Jr, Park F, Maeda CY, Cowley AW Jr) Hypertension 2000 Mar;35(3):740-5 44 Citations |
1 | Increase in renal medullary nitric oxide synthase activity protects from norepinephrine-induced hypertension. (Szentiványi M Jr, Zou AP, Maeda CY, Mattson DL, Cowley AW Jr) Hypertension 2000 Jan;35(1 Pt 2):418-23 33 Citations |
1 | Expression and actions of heme oxygenase in the renal medulla of rats. (Zou AP, Billington H, Su N, Cowley AW Jr) Hypertension 2000 Jan;35(1 Pt 2):342-7 91 Citations |
1 | Cloning and preliminary characterization of a calcium-binding protein closely related to nucleolin on the apical surface of inner medullary collecting duct cells. (Sorokina EA, Kleinman JG) J Biol Chem 1999 Sep 24;274(39):27491-6 37 Citations |
1 | Role of renal medullary adenosine in the control of blood flow and sodium excretion. (Zou AP, Nithipatikom K, Li PL, Cowley AW Jr) Am J Physiol 1999 Mar;276(3):R790-8 92 Citations |
1 | Local renal medullary L-NAME infusion enhances the effect of long-term angiotensin II treatment. (Szentiványi M Jr, Maeda CY, Cowley AW Jr) Hypertension 1999 Jan;33(1 Pt 2):440-5 40 Citations |
1 | Renal intramedullary infusion of L-arginine prevents reduction of medullary blood flow and hypertension in Dahl salt-sensitive rats. (Miyata N, Cowley AW Jr) Hypertension 1999 Jan;33(1 Pt 2):446-50 79 Citations |
1 | Arginine vasopressin-mediated stimulation of nitric oxide within the rat renal medulla. (Park F, Zou AP, Cowley AW Jr) Hypertension 1998 Nov;32(5):896-901 52 Citations |
1 | Renal medullary interstitial infusion of L-arginine prevents hypertension in Dahl salt-sensitive rats. (Miyata N, Zou AP, Mattson DL, Cowley AW Jr) Am J Physiol 1998 Nov;275(5):R1667-73 59 Citations |
1 | Effects of long-term vasopressin receptor stimulation on medullary blood flow and arterial pressure. (Cowley AW Jr, Skelton MM, Kurth TM) Am J Physiol 1998 Nov;275(5):R1420-4 33 Citations |
1 | Pharmacological stimulation of arterial chemoreceptors in conscious rats produces differential responses in renal cortical and medullary blood flow. (Ledderhos C, Gross V, Cowley AW Jr) Clin Exp Pharmacol Physiol 1998;25(7-8):536-40 19 Citations |
1 | Effects of daily sodium intake and ANG II on cortical and medullary renal blood flow in conscious rats. (Gross V, Kurth TM, Skelton MM, Mattson DL, Cowley AW Jr) Am J Physiol 1998 May;274(5):R1317-23 43 Citations |
1 | Protective effect of angiotensin II-induced increase in nitric oxide in the renal medullary circulation. (Zou AP, Wu F, Cowley AW Jr) Hypertension 1998 Jan;31(1 Pt 2):271-6 136 Citations |
1 | Inducible nitric oxide synthase and blood pressure. (Mattson DL, Maeda CY, Bachman TD, Cowley AW Jr) Hypertension 1998 Jan;31(1):15-20 80 Citations |
1 | Evidence for the presence of smooth muscle alpha-actin within pericytes of the renal medulla. (Park F, Mattson DL, Roberts LA, Cowley AW Jr) Am J Physiol 1997 Nov;273(5):R1742-8 86 Citations |
1 | Localization of the vasopressin V1a and V2 receptors within the renal cortical and medullary circulation. (Park F, Mattson DL, Skelton MM, Cowley AW Jr) Am J Physiol 1997 Jul;273(1 Pt 2):R243-51 73 Citations |
1 | Role of the renal medulla in volume and arterial pressure regulation. (Cowley AW Jr) Am J Physiol 1997 Jul;273(1 Pt 2):R1-15 218 Citations |
1 | Vasopressin modulation of medullary blood flow and pressure-natriuresis-diuresis in the decerebrated rat. (Franchini KG, Mattson DL, Cowley AW Jr) Am J Physiol 1997 May;272(5 Pt 2):R1472-9 29 Citations |
1 | Nitric oxide in renal cortex and medulla. An in vivo microdialysis study. (Zou AP, Cowley AW Jr) Hypertension 1997 Jan;29(1 Pt 2):194-8 144 Citations |
1 | Sensitivity of the renal medullary circulation to plasma vasopressin. (Franchini KG, Cowley AW Jr) Am J Physiol 1996 Sep;271(3 Pt 2):R647-53 48 Citations |
1 | Renal cortical and medullary blood flow responses during water restriction: role of vasopressin. (Franchini KG, Cowley AW Jr) Am J Physiol 1996 Jun;270(6 Pt 2):R1257-64 65 Citations |
1 | Control of renal medullary blood flow by vasopressin V1 and V2 receptors. (Nakanishi K, Mattson DL, Gross V, Roman RJ, Cowley AW Jr) Am J Physiol 1995 Jul;269(1 Pt 2):R193-200 68 Citations |
1 | The renal medulla and hypertension. (Cowley AW Jr, Mattson DL, Lu S, Roman RJ) Hypertension 1995 Apr;25(4 Pt 2):663-73 213 Citations |
1 | In vivo diuretic actions of renal vasopressin V1 receptor stimulation in rats. (Ledderhos C, Mattson DL, Skelton MM, Cowley AW Jr) Am J Physiol 1995 Mar;268(3 Pt 2):R796-807 17 Citations |
1 | Role of renal medullary blood flow in the development of L-NAME hypertension in rats. (Nakanishi K, Mattson DL, Cowley AW Jr) Am J Physiol 1995 Feb;268(2 Pt 2):R317-23 100 Citations |
1 | Franz Volhard Lecture. Evolution of the medullipin concept of blood pressure control: a tribute to Eric Muirhead. (Cowley AW Jr) J Hypertens Suppl 1994 Dec;12(10):S25-34 16 Citations |
1 | Prolonged stimulation of intrarenal V1 vasopressin receptors results in sustained hypertension. (Szczepanska-Sadowska E, Stepniakowski K, Skelton MM, Cowley AW Jr) Am J Physiol 1994 Nov;267(5 Pt 2):R1217-25 40 Citations |
2 | Effect of chronic renal medullary nitric oxide inhibition on blood pressure. (Mattson DL, Lu S, Nakanishi K, Papanek PE, Cowley AW Jr) Am J Physiol 1994 May;266(5 Pt 2):H1918-26 194 Citations |
1 | Renal medullary captopril delivery lowers blood pressure in spontaneously hypertensive rats. (Lu S, Mattson DL, Cowley AW Jr) Hypertension 1994 Mar;23(3):337-45 80 Citations |
1 | ddAVP does not stimulate acute changes in levels of medullary trimethylamines in humans. (Avison MJ, Van Why SK, Siegel NJ) J Am Soc Nephrol 1993 Dec;4(6):1379-84 |
1 | Kinin actions on renal papillary blood flow and sodium excretion. (Mattson DL, Cowley AW Jr) Hypertension 1993 Jun;21(6 Pt 2):961-5 87 Citations |
1 | Relationship between renal perfusion pressure and blood flow in different regions of the kidney. (Mattson DL, Lu S, Roman RJ, Cowley AW Jr) Am J Physiol 1993 Mar;264(3 Pt 2):R578-83 135 Citations |
1 | Renal medullary interstitial infusion of diltiazem alters sodium and water excretion in rats. (Lu S, Roman RJ, Mattson DL, Cowley AW Jr) Am J Physiol 1992 Nov;263(5 Pt 2):R1064-70 64 Citations |
1 | Abnormal sodium pump distribution during renal tubulogenesis in congenital murine polycystic kidney disease. (Avner ED, Sweeney WE Jr, Nelson WJ) Proc Natl Acad Sci U S A 1992 Aug 15;89(16):7447-51 98 Citations |
1 | Role of nitric oxide in renal papillary blood flow and sodium excretion. (Mattson DL, Roman RJ, Cowley AW Jr) Hypertension 1992 Jun;19(6 Pt 2):766-9 218 Citations |
1 | Influence of angiotensin II on pressure natriuresis and renal hemodynamics in volume-expanded rats. (Mattson DL, Raff H, Roman RJ) Am J Physiol 1991 Jun;260(6 Pt 2):R1200-9 57 Citations |
1 | Regulation of pH in rat papillary tubule cells in primary culture. (Kleinman JG, Blumenthal SS, Wiessner JH, Reetz KL, Lewand DL, Mandel NS, Mandel GS, Garancis JC, Cragoe EJ Jr) J Clin Invest 1987 Dec;80(6):1660-9 35 Citations |
1 | Atriopeptin III alters renal medullary hemodynamics and the pressure-diuresis response in rats. (Takezawa K, Cowley AW Jr, Skelton M, Roman RJ) Am J Physiol 1987 Jun;252(6 Pt 2):F992-1002 79 Citations |
1 | Cortical and papillary micropuncture examination of chloride transport in segments of the rat kidney during inhibition of prostaglandin production. Possible role for prostaglandins in the chloruresis of acute volume expansion. (Higashihara E, Stokes JB, Kokko JP, Campbell WB, DuBose TD Jr) J Clin Invest 1979 Nov;64(5):1277-87 90 Citations |