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1 | MTORC1/2 Inhibition as a Therapeutic Strategy for PIK3CA Mutant Cancers. (Fricke SL, Payne SN, Favreau PF, Kratz JD, Pasch CA, Foley TM, Yueh AE, Van De Hey DR, Depke MG, Korkos DP, Sha GC, DeStefanis RA, Clipson L, Burkard ME, Lemmon KK, Parsons BM, Kenny PA, Matkowskyj KA, Newton MA, Skala MC, Deming DA) Mol Cancer Ther 2019 Feb;18(2):346-355 23 Citations |
1 | Montelukast for Children with Obstructive Sleep Apnea: Results of a Double-Blind, Randomized, Placebo-Controlled Trial. (Kheirandish-Gozal L, Bandla HP, Gozal D) Ann Am Thorac Soc 2016 Oct;13(10):1736-1741 96 Citations |
1 | 17β-Estradiol and Agonism of G-protein-Coupled Estrogen Receptor Enhance Hippocampal Memory via Different Cell-Signaling Mechanisms. (Kim J, Szinte JS, Boulware MI, Frick KM) J Neurosci 2016 Mar 16;36(11):3309-21 108 Citations |
1 | Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K. (Yueh AE, Payne SN, Leystra AA, Van De Hey DR, Foley TM, Pasch CA, Clipson L, Matkowskyj KA, Deming DA) PLoS One 2016;11(2):e0148730 15 Citations |
1 | First-in-Human Phase I Study of GSK2126458, an Oral Pan-Class I Phosphatidylinositol-3-Kinase Inhibitor, in Patients with Advanced Solid Tumor Malignancies. (Munster P, Aggarwal R, Hong D, Schellens JH, van der Noll R, Specht J, Witteveen PO, Werner TL, Dees EC, Bergsland E, Agarwal N, Kleha JF, Durante M, Adams L, Smith DA, Lampkin TA, Morris SR, Kurzrock R) Clin Cancer Res 2016 Apr 15;22(8):1932-9 73 Citations |
1 | Phase 1b study of lenvatinib (E7080) in combination with temozolomide for treatment of advanced melanoma. (Hong DS, Kurzrock R, Falchook GS, Andresen C, Kwak J, Ren M, Xu L, George GC, Kim KB, Nguyen LM, O'Brien JP, Nemunaitis J) Oncotarget 2015 Dec 15;6(40):43127-34 19 Citations |
1 | Phase I Dose-Escalation Study of the Multikinase Inhibitor Lenvatinib in Patients with Advanced Solid Tumors and in an Expanded Cohort of Patients with Melanoma. (Hong DS, Kurzrock R, Wheler JJ, Naing A, Falchook GS, Fu S, Kim KB, Davies MA, Nguyen LM, George GC, Xu L, Shumaker R, Ren M, Mink J, Bedell C, Andresen C, Sachdev P, O'Brien JP, Nemunaitis J) Clin Cancer Res 2015 Nov 01;21(21):4801-10 60 Citations |
1 | The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer. (Bean JR, Hosford SR, Symonds LK, Owens P, Dillon LM, Yang W, Shee K, Schwartz GN, Marotti JD, Muller KE, Rosenkranz KM, Barth RJ, Chen VS, Agarwal VR, Miller TW) Breast Cancer Res Treat 2015 Jan;149(1):69-79 13 Citations |
1 | Tumor marker and measurement fluctuations may not reflect treatment efficacy in patients with medullary thyroid carcinoma on long-term RET inhibitor therapy. (Kurzrock R, Atkins J, Wheler J, Fu S, Naing A, Busaidy N, Hong D, Sherman S) Ann Oncol 2013 Sep;24(9):2256-61 26 Citations |
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1 | Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation. (Tanaka S, Fukumoto Y, Nochioka K, Minami T, Kudo S, Shiba N, Takai Y, Williams CL, Liao JK, Shimokawa H) Arterioscler Thromb Vasc Biol 2013 Jul;33(7):1591-600 73 Citations |
1 | Metabotropic glutamate receptor I (mGluR1) antagonism impairs cocaine-induced conditioned place preference via inhibition of protein synthesis. (Yu F, Zhong P, Liu X, Sun D, Gao HQ, Liu QS) Neuropsychopharmacology 2013 Jun;38(7):1308-21 44 Citations |
1 | Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand. (Clark AH, McCorvy JD, Conley JM, Williams WK, Bekkam M, Watts VJ, Nichols DE) Bioorg Med Chem 2012 Nov 01;20(21):6366-74 9 Citations |
1 | Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndrome. (Fleseriu M, Biller BM, Findling JW, Molitch ME, Schteingart DE, Gross C, SEISMIC Study Investigators) J Clin Endocrinol Metab 2012 Jun;97(6):2039-49 365 Citations |
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1 | A comparison of the pharmacokinetics of the anticancer MET inhibitor foretinib free base tablet formulation to bisphosphate salt capsule formulation in patients with solid tumors. (Naing A, Kurzrock R, Adams LM, Kleha JF, Laubscher KH, Bonate PL, Weller S, Fitzgerald C, Xu Y, LoRusso PM) Invest New Drugs 2012 Feb;30(1):327-34 17 Citations |
1 | Urinary cysteinyl leukotriene E4 significantly increases during pain in children and adults with sickle cell disease. (Field JJ, Strunk RC, Knight-Perry JE, Blinder MA, Townsend RR, DeBaun MR) Am J Hematol 2009 Apr;84(4):231-3 24 Citations |
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1 | Src inhibition ameliorates polycystic kidney disease. (Sweeney WE Jr, von Vigier RO, Frost P, Avner ED) J Am Soc Nephrol 2008 Jul;19(7):1331-41 130 Citations |
1 | Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii. (Smith AT, Livingston MR, Mai A, Filetici P, Queener SF, Sullivan WJ Jr) Antimicrob Agents Chemother 2007 Mar;51(3):1109-11 31 Citations |
1 | Assessing the reliability of amplified RNA used in microarrays: a DUMB table approach. (Bearden ED, Simpson PM, Peterson CA, Beggs ML) Appl Bioinformatics 2006;5(2):67-76 2 Citations |
1 | Scope and mechanistic study of the ruthenium-catalyzed ortho-C-H bond activation and cyclization reactions of arylamines with terminal alkynes. (Yi CS, Yun SY) J Am Chem Soc 2005 Dec 07;127(48):17000-6 143 Citations |
4 | Comparative in vitro antimicrobial activity of a novel quinolone, garenoxacin, against aerobic and anaerobic microbial isolates recovered from general, vascular, cardiothoracic and otolaryngologic surgical patients. (Edmiston CE Jr, Krepel CJ, Kehl KS, Seabrook GR, Somberg LB, Almassi GH, Smith TL, Loehrl TA, Brown KR, Lewis BD, Towne JB) J Antimicrob Chemother 2005 Nov;56(5):872-8 15 Citations |
1 | Ruthenium-catalyzed intermolecular coupling reactions of arylamines with ethylene and 1,3-dienes: mechanistic insight on hydroamination vs ortho-C-H bond activation. (Yi CS, Yun SY) Org Lett 2005 May 26;7(11):2181-3 75 Citations |
1 | Catalytic synthesis of tricyclic quinoline derivatives from the regioselective hydroamination and C-H bond activation reaction of benzocyclic amines and alkynes. (Yi CS, Yun SY, Guzei IA) J Am Chem Soc 2005 Apr 27;127(16):5782-3 110 Citations |
1 | Phase I study of docetaxel in combination with the P-glycoprotein inhibitor, zosuquidar, in resistant malignancies. (Fracasso PM, Goldstein LJ, de Alwis DP, Rader JS, Arquette MA, Goodner SA, Wright LP, Fears CL, Gazak RJ, Andre VA, Burgess MF, Slapak CA, Schellens JH) Clin Cancer Res 2004 Nov 01;10(21):7220-8 69 Citations |
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1 | Opioid-induced second window of cardioprotection: potential role of mitochondrial KATP channels. (Fryer RM, Hsu AK, Eells JT, Nagase H, Gross GJ) Circ Res 1999 Apr 16;84(7):846-51 206 Citations |