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Publications indexed to the term Transduction, Genetic

1AAV-Mediated Gene Transfer Restores a Normal Muscle Transcriptome in a Canine Model of X-Linked Myotubular Myopathy. (Dupont JB, Guo J, Renaud-Gabardos E, Poulard K, Latournerie V, Lawlor MW, Grange RW, Gray JT, Buj-Bello A, Childers MK, Mack DL) Mol Ther 2020 02 05;28(2):382-393       5 Citations
2The impact of GPIbα on platelet-targeted FVIII gene therapy in hemophilia A mice with pre-existing anti-FVIII immunity. (Chen J, Schroeder JA, Luo X, Montgomery RR, Shi Q) J Thromb Haemost 2019 03;17(3):449-459       7 Citations
1Intravenous Administration of a MTMR2-Encoding AAV Vector Ameliorates the Phenotype of Myotubular Myopathy in Mice. (Danièle N, Moal C, Julien L, Marinello M, Jamet T, Martin S, Vignaud A, Lawlor MW, Buj-Bello A) J Neuropathol Exp Neurol 2018 04 01;77(4):282-295       7 Citations
2Closed-system manufacturing of CD19 and dual-targeted CD20/19 chimeric antigen receptor T cells using the CliniMACS Prodigy device at an academic medical center. (Zhu F, Shah N, Xu H, Schneider D, Orentas R, Dropulic B, Hari P, Keever-Taylor CA) Cytotherapy 2018 03;20(3):394-406       27 Citations
1Improvement of Photoreceptor Targeting via Intravitreal Delivery in Mouse and Human Retina Using Combinatory rAAV2 Capsid Mutant Vectors. (Reid CA, Ertel KJ, Lipinski DM) Invest Ophthalmol Vis Sci 2017 12 01;58(14):6429-6439       14 Citations
2A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses. (Hong SK, Wu PK, Park JI) Cell Signal 2018 Jan;42:11-20       6 Citations
1Glial fibrillary acidic protein promoter determines transgene expression in satellite glial cells following intraganglionic adeno-associated virus delivery in adult rats. (Xiang H, Xu H, Fan F, Shin SM, Hogan QH, Yu H) J Neurosci Res 2018 03;96(3):436-448       6 Citations
1Immune tolerance induced by platelet-targeted factor VIII gene therapy in hemophilia A mice is CD4 T cell mediated. (Chen Y, Luo X, Schroeder JA, Chen J, Baumgartner CK, Hu J, Shi Q) J Thromb Haemost 2017 10;15(10):1994-2004       18 Citations
1Long-term effects of systemic gene therapy in a canine model of myotubular myopathy. (Elverman M, Goddard MA, Mack D, Snyder JM, Lawlor MW, Meng H, Beggs AH, Buj-Bello A, Poulard K, Marsh AP, Grange RW, Kelly VE, Childers MK) Muscle Nerve 2017 Nov;56(5):943-953       29 Citations
2AAV-Mediated Gene Transfer to Dorsal Root Ganglion. (Yu H, Fischer G, Hogan QH) Methods Mol Biol 2016;1382:251-61       8 Citations
1Systemic Vascular Transduction by Capsid Mutant Adeno-Associated Virus After Intravenous Injection. (Lipinski DM, Reid CA, Boye SL, Peterson JJ, Qi X, Boye SE, Boulton ME, Hauswirth WW) Hum Gene Ther 2015 Nov;26(11):767-76       6 Citations
1Inhibition of JAK2 Reverses Paclitaxel Resistance in Human Ovarian Cancer Cells. (Xu Y, Zhang J, Wu J, Zhong S, Li H) Int J Gynecol Cancer 2015 Nov;25(9):1557-64       11 Citations
1Evaluation of Bystander Cell Killing Effects in Suicide Gene Therapy of Cancer: Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis. (Sato T, Neschadim A, Nakagawa R, Yanagisawa T, Medin JA) Methods Mol Biol 2015;1317:55-67       2 Citations
1In vivo evaluation of adeno-associated virus gene transfer in airways of mice with acute or chronic respiratory infection. (Myint M, Limberis MP, Bell P, Somanathan S, Haczku A, Wilson JM, Diamond SL) Hum Gene Ther 2014 Nov;25(11):966-76       7 Citations
1Vesicular stomatitis virus glycoprotein- and Venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors. (Lipinski DM, Barnard AR, Charbel Issa P, Singh MS, De Silva SR, Trabalza A, Eleftheriadou I, Ellison SM, Mazarakis ND, MacLaren RE) Hum Gene Ther 2014 Jan;25(1):50-62       18 Citations
1Platelet gene therapy by lentiviral gene delivery to hematopoietic stem cells restores hemostasis and induces humoral immune tolerance in FIX(null) mice. (Chen Y, Schroeder JA, Kuether EL, Zhang G, Shi Q) Mol Ther 2014 Jan;22(1):169-77       39 Citations
1Engineering lentiviral vectors for modulation of dendritic cell apoptotic pathways. (Wang JC, Felizardo TC, Au BC, Fowler DH, Dekaban GA, Medin JA) Virol J 2013 Jul 20;10:240       4 Citations
1Harnessing autophagy for cell fate control gene therapy. (Felizardo TC, Foley J, Steed K, Dropulic B, Amarnath S, Medin JA, Fowler DH) Autophagy 2013 Jul;9(7):1069-79       5 Citations
1Assessment of tropism and effectiveness of new primate-derived hybrid recombinant AAV serotypes in the mouse and primate retina. (Charbel Issa P, De Silva SR, Lipinski DM, Singh MS, Mouravlev A, You Q, Barnard AR, Hankins MW, During MJ, Maclaren RE) PLoS One 2013;8(4):e60361       25 Citations
1Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo. (Palomares K, Vigant F, Van Handel B, Pernet O, Chikere K, Hong P, Sherman SP, Patterson M, An DS, Lowry WE, Mikkola HK, Morizono K, Pyle AD, Lee B) J Virol 2013 Feb;87(4):2094-108    
1Neonatal transfer of membrane-bound stem cell factor improves survival and heart function in aged mice after myocardial ischemia. (Sun Z, Lee CJ, Mejia-Guerrero S, Zhang Y, Higuchi K, Li RK, Medin JA) Hum Gene Ther 2012 Dec;23(12):1280-9       3 Citations
3Decreases in manganese superoxide dismutase expression and activity contribute to oxidative stress in persistent pulmonary hypertension of the newborn. (Afolayan AJ, Eis A, Teng RJ, Bakhutashvili I, Kaul S, Davis JM, Konduri GG) Am J Physiol Lung Cell Mol Physiol 2012 Nov 15;303(10):L870-9       54 Citations
3Lentivirus-mediated platelet gene therapy of murine hemophilia A with pre-existing anti-factor VIII immunity. (Kuether EL, Schroeder JA, Fahs SA, Cooley BC, Chen Y, Montgomery RR, Wilcox DA, Shi Q) J Thromb Haemost 2012 Aug;10(8):1570-80       79 Citations
1Lentivector transduction improves outcomes over transplantation of human HSCs alone in NOD/SCID/Fabry mice. (Pacienza N, Yoshimitsu M, Mizue N, Au BC, Wang JC, Fan X, Takenaka T, Medin JA) Mol Ther 2012 Jul;20(7):1454-61       14 Citations
1Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase. (Neschadim A, Wang JC, Sato T, Fowler DH, Lavie A, Medin JA) Mol Ther 2012 May;20(5):1002-13       15 Citations
2Lentiviral gene transfer into the dorsal root ganglion of adult rats. (Yu H, Fischer G, Jia G, Reiser J, Park F, Hogan QH) Mol Pain 2011 Aug 23;7:63       35 Citations
1Autologous transplantation of lentivector/acid ceramidase-transduced hematopoietic cells in nonhuman primates. (Walia JS, Neschadim A, Lopez-Perez O, Alayoubi A, Fan X, Carpentier S, Madden M, Lee CJ, Cheung F, Jaffray DA, Levade T, McCart JA, Medin JA) Hum Gene Ther 2011 Jun;22(6):679-87       22 Citations
1A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs. (Likar Y, Zurita J, Dobrenkov K, Shenker L, Cai S, Neschadim A, Medin JA, Sadelain M, Hricak H, Ponomarev V) J Nucl Med 2010 Sep;51(9):1395-403       41 Citations
1Endothelin signaling via guanine exchange factor C3G in renal glomerular mesangial cells. (Rufanova VA, Alexanian A, Ostendorf T, Bokemeyer D, Prosser S, Miller B, Sorokin A) Can J Physiol Pharmacol 2010 Aug;88(8):808-16       4 Citations
1Alpha-galactosidase A-Tat fusion enhances storage reduction in hearts and kidneys of Fabry mice. (Higuchi K, Yoshimitsu M, Fan X, Guo X, Rasaiah VI, Yen J, Tei C, Takenaka T, Medin JA) Mol Med 2010 May-Jun;16(5-6):216-21       10 Citations
1Induction of human blood group a antigen expression on mouse cells, using lentiviral gene transduction. (Fan X, Lang H, Zhou X, Zhang L, Yin R, Maciejko J, Giannitsos V, Motyka B, Medin JA, Platt JL, West LJ) Hum Gene Ther 2010 Jul;21(7):877-90       10 Citations
1Vascular endothelial growth factor broadens lentivector distribution in the heart after neonatal injection. (Sato T, Ramsubir S, Higuchi K, Yanagisawa T, Medin JA) J Cardiol 2009 Oct;54(2):245-54       5 Citations
1The noninvasive, quantitative, in vivo assessment of adenoviral-mediated gene delivery in skin wound biomaterials. (Peterson CY, Shaterian A, Borboa AK, Gonzalez AM, Potenza BM, Coimbra R, Eliceiri BP, Baird A) Biomaterials 2009 Dec;30(35):6788-93       10 Citations
1Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells. (Symes JC, Siatskas C, Fowler DH, Medin JA) Cancer Gene Ther 2009 May;16(5):439-52       6 Citations
1The SWI/SNF chromatin-remodeling complex and glucocorticoid resistance in acute lymphoblastic leukemia. (Pottier N, Yang W, Assem M, Panetta JC, Pei D, Paugh SW, Cheng C, Den Boer ML, Relling MV, Pieters R, Evans WE, Cheok MH) J Natl Cancer Inst 2008 Dec 17;100(24):1792-803       42 Citations
1Characterization of SLC26A9, facilitation of Cl(-) transport by bicarbonate. (Loriol C, Dulong S, Avella M, Gabillat N, Boulukos K, Borgese F, Ehrenfeld J) Cell Physiol Biochem 2008;22(1-4):15-30       50 Citations
1Transduction and transplantation of spermatogonia into the testis of ram lambs through the extra-testicular rete. (Rodriguez-Sosa JR, Silvertown JD, Foster RA, Medin JA, Hahnel A) Reprod Domest Anim 2009 Aug;44(4):612-20       17 Citations
1Modulation of cellular invasion by VEGF-C expression in squamous cell carcinoma of the head and neck. (Bock JM, Sinclair LL, Bedford NS, Jackson RE, Lee JH, Trask DK) Arch Otolaryngol Head Neck Surg 2008 Apr;134(4):355-62       22 Citations
1Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology. (Der Sarkissian S, Grobe JL, Yuan L, Narielwala DR, Walter GA, Katovich MJ, Raizada MK) Hypertension 2008 Mar;51(3):712-8       113 Citations
1Tumor protection following vaccination with low doses of lentivirally transduced DCs expressing the self-antigen erbB2. (Mossoba ME, Walia JS, Rasaiah VI, Buxhoeveden N, Head R, Ying C, Foley JE, Bramson JL, Fowler DH, Medin JA) Mol Ther 2008 Mar;16(3):607-17       22 Citations
1Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway. (Lowe JS, Palygin O, Bhasin N, Hund TJ, Boyden PA, Shibata E, Anderson ME, Mohler PJ) J Cell Biol 2008 Jan 14;180(1):173-86       130 Citations
2Suppression of 11beta-hydroxysteroid dehydrogenase type 1 with RNA interference substantially attenuates 3T3-L1 adipogenesis. (Liu Y, Park F, Pietrusz JL, Jia G, Singh RJ, Netzel BC, Liang M) Physiol Genomics 2008 Feb 19;32(3):343-51       28 Citations
1ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts. (Grobe JL, Der Sarkissian S, Stewart JM, Meszaros JG, Raizada MK, Katovich MJ) Clin Sci (Lond) 2007 Oct;113(8):357-64       69 Citations
4Lentivirus-mediated platelet-derived factor VIII gene therapy in murine haemophilia A. (Shi Q, Wilcox DA, Fahs SA, Fang J, Johnson BD, DU LM, Desai D, Montgomery RR) J Thromb Haemost 2007 Feb;5(2):352-61       99 Citations
1Lentivirally transduced recipient-derived dendritic cells serve to ex vivo expand functional FcRgamma-sufficient double-negative regulatory T cells. (Thomson CW, Mossoba ME, Siatskas C, Chen W, Sung A, Medin JA, Zhang L) Mol Ther 2007 Apr;15(4):818-24       3 Citations
1Genetically selected stem cells from human adipose tissue express cardiac markers. (Bai X, Pinkernell K, Song YH, Nabzdyk C, Reiser J, Alt E) Biochem Biophys Res Commun 2007 Feb 16;353(3):665-71       58 Citations
1Cancer immunotherapy using virally transduced dendritic cells: animal studies and human clinical trials. (Mossoba ME, Medin JA) Expert Rev Vaccines 2006 Oct;5(5):717-32       23 Citations
1Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor. (Li H, Gao Y, Grobe JL, Raizada MK, Katovich MJ, Sumners C) Am J Physiol Heart Circ Physiol 2007 Feb;292(2):H727-35       23 Citations
1Adenoviral expression of 15-lipoxygenase-1 in rabbit aortic endothelium: role in arachidonic acid-induced relaxation. (Aggarwal NT, Holmes BB, Cui L, Viita H, Yla-Herttuala S, Campbell WB) Am J Physiol Heart Circ Physiol 2007 Feb;292(2):H1033-41       14 Citations
1Efficient correction of Fabry mice and patient cells mediated by lentiviral transduction of hematopoietic stem/progenitor cells. (Yoshimitsu M, Higuchi K, Ramsubir S, Nonaka T, Rasaiah VI, Siatskas C, Liang SB, Murray GJ, Brady RO, Medin JA) Gene Ther 2007 Feb;14(3):256-65       37 Citations
1Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. (Behrstock S, Ebert A, McHugh J, Vosberg S, Moore J, Schneider B, Capowski E, Hei D, Kordower J, Aebischer P, Svendsen CN) Gene Ther 2006 Mar;13(5):379-88       135 Citations
1Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. (Campbell WB, Holmes BB, Falck JR, Capdevila JH, Gauthier KM) Am J Physiol Heart Circ Physiol 2006 Jan;290(1):H64-71       23 Citations
1Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. (Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK) Exp Physiol 2005 Sep;90(5):783-90       188 Citations
1H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis. (Silvertown JD, Ng J, Sato T, Summerlee AJ, Medin JA) Int J Cancer 2006 Jan 01;118(1):62-73       69 Citations
1Cloning, sequencing and characterization of lentiviral-mediated expression of rhesus macaque (Macaca mulatta) interleukin-2 receptor alpha cDNA. (Silvertown JD, Walia JS, Medin JA) Dev Comp Immunol 2005;29(11):989-1002       2 Citations
1Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome. (Hofstetter CP, Holmström NA, Lilja JA, Schweinhardt P, Hao J, Spenger C, Wiesenfeld-Hallin Z, Kurpad SN, Frisén J, Olson L) Nat Neurosci 2005 Mar;8(3):346-53       493 Citations
3Targeting platelet GPIbalpha transgene expression to human megakaryocytes and forming a complete complex with endogenous GPIbbeta and GPIX. (Shi Q, Wilcox DA, Morateck PA, Fahs SA, Kenny D, Montgomery RR) J Thromb Haemost 2004 Nov;2(11):1989-97       31 Citations
1Enhanced effect of vascular endothelial growth factor, thrombopoietin peptide agonist, SCF, and Flt3-L on LTC-IC and reporter gene transduction from umbilical cord blood CD34+ cells. (Smith SL, Kiss J, Siatskas C, Medin JA, Moldwin RL) Transfusion 2004 Mar;44(3):438-49       2 Citations
5Induction of megakaryocytes to synthesize and store a releasable pool of human factor VIII. (Wilcox DA, Shi Q, Nurden P, Haberichter SL, Rosenberg JB, Johnson BD, Nurden AT, White GC 2nd, Montgomery RR) J Thromb Haemost 2003 Dec;1(12):2477-89       46 Citations
1Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions. (Burt RK, Drobyski WR, Seregina T, Traynor A, Oyama Y, Keever-Taylor C, Stefka J, Kuzel TM, Brush M, Rodriquez J, Burns W, Tennant L, Link C) Exp Hematol 2003 Oct;31(10):903-10       40 Citations
1Post-transduction events in retrovirus-mediated gene therapy involving hematopoietic stem cells: beyond efficiency issues. (Medin JA, Fowler DH) J Cell Biochem Suppl 2002;38:46-54       4 Citations
1Glomerular beta-galactosidase expression following transduction with microsphere-adenoviral complexes. (Bhatt UY, Sferra TJ, Johnson A, Williams C, Shirey K, Venema T, Nuovo GJ, Nahman NS Jr) Kidney Int 2002 Jan;61(1 Suppl):S68-72       5 Citations
1Gene therapy for Fabry disease. (Siatskas C, Medin JA) J Inherit Metab Dis 2001;24 Suppl 2:25-41; discussion 11-2       31 Citations
1Cytomegalovirus-specific cytolytic T-cell lines and clones generated against adenovirus-pp65-infected dendritic cells. (Keever-Taylor CA, Margolis D, Konings S, Sandford GR, Nicolette CA, Lawendowski C, Burns WH) Biol Blood Marrow Transplant 2001;7(5):247-56       30 Citations
1Genetic induction of a releasable pool of factor VIII in human endothelial cells. (Rosenberg JB, Greengard JS, Montgomery RR) Arterioscler Thromb Vasc Biol 2000 Dec;20(12):2689-95       65 Citations
1Circulating alpha-galactosidase A derived from transduced bone marrow cells: relevance for corrective gene transfer for Fabry disease. (Takenaka T, Qin G, Brady RO, Medin JA) Hum Gene Ther 1999 Aug 10;10(12):1931-9       36 Citations
1Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments]. (Bouvet M, Bold RJ, Lee J, Evans DB, Abbruzzese JL, Chiao PJ, McConkey DJ, Chandra J, Chada S, Fang B, Roth JA) Ann Surg Oncol 1998 Dec;5(8):681-8       113 Citations
1Selection of retrovirally transduced cells to enhance the efficiency of gene therapy. (Medin JA, Karlsson S) Proc Assoc Am Physicians 1997 Mar;109(2):111-9       11 Citations
1Selection of transduced CD34+ progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectors. (Migita M, Medin JA, Pawliuk R, Jacobson S, Nagle JW, Anderson S, Amiri M, Humphries RK, Karlsson S) Proc Natl Acad Sci U S A 1995 Dec 19;92(26):12075-9       50 Citations
1Transfer of the human glucocerebrosidase gene into hematopoietic stem cells of nonablated recipients: successful engraftment and long-term expression of the transgene. (Schiffmann R, Medin JA, Ward JM, Stahl S, Cottler-Fox M, Karlsson S) Blood 1995 Aug 01;86(3):1218-27       41 Citations
1Inactivation of mismatch repair overcomes the barrier to transduction between Salmonella typhimurium and Salmonella typhi. (Zahrt TC, Mora GC, Maloy S) J Bacteriol 1994 Mar;176(5):1527-9       49 Citations