| 2 | Patterns of somatic structural variation in human cancer genomes. (Li Y, Roberts ND, Wala JA, Shapira O, Schumacher SE, Kumar K, Khurana E, Waszak S, Korbel JO, Haber JE, Imielinski M, PCAWG Structural Variation Working Group, Weischenfeldt J, Beroukhim R, Campbell PJ, PCAWG Consortium) Nature 2020 Feb;578(7793):112-121 637 Citations |
| 2 | The evolutionary history of 2,658 cancers. (Gerstung M, Jolly C, Leshchiner I, Dentro SC, Gonzalez S, Rosebrock D, Mitchell TJ, Rubanova Y, Anur P, Yu K, Tarabichi M, Deshwar A, Wintersinger J, Kleinheinz K, Vázquez-García I, Haase K, Jerman L, Sengupta S, Macintyre G, Malikic S, Donmez N, Livitz DG, Cmero M, Demeulemeester J, Schumacher S, Fan Y, Yao X, Lee J, Schlesner M, Boutros PC, Bowtell DD, Zhu H, Getz G, Imielinski M, Beroukhim R, Sahinalp SC, Ji Y, Peifer M, Markowetz F, Mustonen V, Yuan K, Wang W, Morris QD, PCAWG Evolution & Heterogeneity Working Group, Spellman PT, Wedge DC, Van Loo P, PCAWG Consortium) Nature 2020 Feb;578(7793):122-128 798 Citations |
| 1 | Knockout of P2rx7 purinergic receptor attenuates cyst growth in a rat model of ARPKD. (Arkhipov SN, Potter DL, Geurts AM, Pavlov TS) Am J Physiol Renal Physiol 2019 Dec 01;317(6):F1649-F1655 23 Citations |
| 1 | Titrating Gene Function in the Human Fungal Pathogen Candida albicans through Poly-Adenosine Tract Insertion. (Tournu H, Butts A, Palmer GE) mSphere 2019 May 22;4(3) 5 Citations |
| 1 | Generation of human iPSCs from urine derived cells of a patient with a novel homozygous PAI-1 mutation. (Afzal MZ, Gartz M, Klyachko EA, Khan SS, Shah SJ, Gupta S, Shapiro AD, Vaughan DE, Strande JL) Stem Cell Res 2016 Nov;17(3):657-660 3 Citations |
| 2 | Identification of Functions Affecting Predator-Prey Interactions between Myxococcus xanthus and Bacillus subtilis. (Müller S, Strack SN, Ryan SE, Shawgo M, Walling A, Harris S, Chambers C, Boddicker J, Kirby JR) J Bacteriol 2016 Dec 15;198(24):3335-3344 35 Citations |
| 1 | Evolution of the Stx2-encoding prophage in persistent bovine Escherichia coli O157:H7 strains. (Park D, Stanton E, Ciezki K, Parrell D, Bozile M, Pike D, Forst SA, Jeong KC, Ivanek R, Döpfer D, Kaspar CW) Appl Environ Microbiol 2013 Mar;79(5):1563-72 21 Citations |
| 7 | IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy. (Schmitt EG, Haribhai D, Williams JB, Aggarwal P, Jia S, Charbonnier LM, Yan K, Lorier R, Turner A, Ziegelbauer J, Georgiev P, Simpson P, Salzman NH, Hessner MJ, Broeckel U, Chatila TA, Williams CB) J Immunol 2012 Dec 15;189(12):5638-48 78 Citations |
| 3 | Lentivirus-mediated platelet gene therapy of murine hemophilia A with pre-existing anti-factor VIII immunity. (Kuether EL, Schroeder JA, Fahs SA, Cooley BC, Chen Y, Montgomery RR, Wilcox DA, Shi Q) J Thromb Haemost 2012 Aug;10(8):1570-80 95 Citations |
| 1 | Combining M-FISH and Quantum Dot technology for fast chromosomal assignment of transgenic insertions. (Yusuf M, Bauer DL, Lipinski DM, MacLaren RE, Wade-Martins R, Mir KU, Volpi EV) BMC Biotechnol 2011 Dec 13;11:121 6 Citations |
| 1 | Functional analysis of the Hsf4(lop11) allele responsible for cataracts in lop11 mice. (Liang L, Liegel R, Endres B, Ronchetti A, Chang B, Sidjanin DJ) Mol Vis 2011;17:3062-71 6 Citations |
| 1 | Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus. (Bonnefond A, Lomberk G, Buttar N, Busiah K, Vaillant E, Lobbens S, Yengo L, Dechaume A, Mignot B, Simon A, Scharfmann R, Neve B, Tanyolaç S, Hodoglugil U, Pattou F, Cavé H, Iovanna J, Stein R, Polak M, Vaxillaire M, Froguel P, Urrutia R) J Biol Chem 2011 Aug 12;286(32):28414-24 72 Citations |
| 1 | Modified needle-tip PcrV proteins reveal distinct phenotypes relevant to the control of type III secretion and intoxication by Pseudomonas aeruginosa. (Sato H, Hunt ML, Weiner JJ, Hansen AT, Frank DW) PLoS One 2011 Mar 29;6(3):e18356 28 Citations |
| 1 | Anaplastic plasmacytoma of mouse--establishing parallels between subtypes of mouse and human plasma cell neoplasia. (de Jong D, Janz S) J Pathol 2010 Jul;221(3):242-7 2 Citations |
| 1 | Activation of ExoU phospholipase activity requires specific C-terminal regions. (Schmalzer KM, Benson MA, Frank DW) J Bacteriol 2010 Apr;192(7):1801-12 26 Citations |
| 1 | Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity. (Boonen M, Vogel P, Platt KA, Dahms N, Kornfeld S) Mol Biol Cell 2009 Oct;20(20):4381-9 27 Citations |
| 1 | Francisella tularensis genes required for inhibition of the neutrophil respiratory burst and intramacrophage growth identified by random transposon mutagenesis of strain LVS. (Schulert GS, McCaffrey RL, Buchan BW, Lindemann SR, Hollenback C, Jones BD, Allen LA) Infect Immun 2009 Apr;77(4):1324-36 64 Citations |
| 1 | Development and use of an efficient system for random mariner transposon mutagenesis to identify novel genetic determinants of biofilm formation in the core Enterococcus faecalis genome. (Kristich CJ, Nguyen VT, Le T, Barnes AM, Grindle S, Dunny GM) Appl Environ Microbiol 2008 Jun;74(11):3377-86 92 Citations |
| 1 | Identification of differentially regulated francisella tularensis genes by use of a newly developed Tn5-based transposon delivery system. (Buchan BW, McLendon MK, Jones BD) Appl Environ Microbiol 2008 May;74(9):2637-45 30 Citations |
| 1 | Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy. (Hackett CS, Geurts AM, Hackett PB) Genome Biol 2007;8 Suppl 1(Suppl 1):S12 52 Citations |
| 2 | Identification of Francisella tularensis Himar1-based transposon mutants defective for replication in macrophages. (Maier TM, Casey MS, Becker RH, Dorsey CW, Glass EM, Maltsev N, Zahrt TC, Frank DW) Infect Immun 2007 Nov;75(11):5376-89 75 Citations |
| 1 | Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system. (Lu B, Geurts AM, Poirier C, Petit DC, Harrison W, Overbeek PA, Bishop CE) Mamm Genome 2007 May;18(5):338-46 72 Citations |
| 1 | In vivo mutagenesis using EZ-Tn5. (Kirby JR) Methods Enzymol 2007;421:17-21 13 Citations |
| 1 | Elimination of channel-forming activity by insertional inactivation of the p66 gene in Borrelia burgdorferi. (Pinne M, Thein M, Denker K, Benz R, Coburn J, Bergström S) FEMS Microbiol Lett 2007 Jan;266(2):241-9 35 Citations |
| 2 | Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. (Geurts AM, Collier LS, Geurts JL, Oseth LL, Bell ML, Mu D, Lucito R, Godbout SA, Green LE, Lowe SW, Hirsch BA, Leinwand LA, Largaespada DA) PLoS Genet 2006 Sep 29;2(9):e156 85 Citations |
| 1 | Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. (Geurts AM, Wilber A, Carlson CM, Lobitz PD, Clark KJ, Hackett PB, McIvor RS, Largaespada DA) BMC Biotechnol 2006 Jun 26;6:30 36 Citations |
| 1 | Analysis of the PixA inclusion body protein of Xenorhabdus nematophila. (Goetsch M, Owen H, Goldman B, Forst S) J Bacteriol 2006 Apr;188(7):2706-10 34 Citations |
| 2 | In vivo Himar1-based transposon mutagenesis of Francisella tularensis. (Maier TM, Pechous R, Casey M, Zahrt TC, Frank DW) Appl Environ Microbiol 2006 Mar;72(3):1878-85 79 Citations |
| 1 | RNA as a source of transposase for Sleeping Beauty-mediated gene insertion and expression in somatic cells and tissues. (Wilber A, Frandsen JL, Geurts JL, Largaespada DA, Hackett PB, McIvor RS) Mol Ther 2006 Mar;13(3):625-30 109 Citations |
| 1 | Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells. (Calmels B, Ferguson C, Laukkanen MO, Adler R, Faulhaber M, Kim HJ, Sellers S, Hematti P, Schmidt M, von Kalle C, Akagi K, Donahue RE, Dunbar CE) Blood 2005 Oct 01;106(7):2530-3 136 Citations |
| 1 | Target-site preferences of Sleeping Beauty transposons. (Liu G, Geurts AM, Yae K, Srinivasan AR, Fahrenkrug SC, Largaespada DA, Takeda J, Horie K, Olson WK, Hackett PB) J Mol Biol 2005 Feb 11;346(1):161-73 119 Citations |
| 1 | Genome-wide transposon mutagenesis of Borrelia burgdorferi for identification of phenotypic mutants. (Stewart PE, Hoff J, Fischer E, Krum JG, Rosa PA) Appl Environ Microbiol 2004 Oct;70(10):5973-9 81 Citations |
| 1 | Transposon vectors for gene-trap insertional mutagenesis in vertebrates. (Clark KJ, Geurts AM, Bell JB, Hackett PB) Genesis 2004 Aug;39(4):225-33 54 Citations |
| 1 | Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers. (Goodfellow PJ, Buttin BM, Herzog TJ, Rader JS, Gibb RK, Swisher E, Look K, Walls KC, Fan MY, Mutch DG) Proc Natl Acad Sci U S A 2003 May 13;100(10):5908-13 215 Citations |
| 1 | The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance. (Pazour GJ, Baker SA, Deane JA, Cole DG, Dickert BL, Rosenbaum JL, Witman GB, Besharse JC) J Cell Biol 2002 Apr 01;157(1):103-13 421 Citations |
| 1 | Vectors for high-level expression of cDNAs controlled by tissue-specific promoters in transgenic mice. (Stec DE, Morimoto S, Sigmund CD) Biotechniques 2001 Aug;31(2):256-8, 260 16 Citations |
| 1 | Inactivation of a novel gene produces a phenotypic variant cell and affects the symbiotic behavior of Xenorhabdus nematophilus. (Volgyi A, Fodor A, Forst S) Appl Environ Microbiol 2000 Apr;66(4):1622-8 22 Citations |
| 1 | Recognition of Dictyostelium discoideum lysosomal enzymes is conferred by the amino-terminal carbohydrate binding site of the insulin-like growth factor II/mannose 6-phosphate receptor. (Marron-Terada PG, Hancock MK, Haskins DJ, Dahms NM) Biochemistry 2000 Mar 07;39(9):2243-53 38 Citations |
| 1 | A single amino acid change in the yeast retrotransposon Ty5 abolishes targeting to silent chromatin. (Gai X, Voytas DF) Mol Cell 1998 Jun;1(7):1051-5 48 Citations |
| 1 | Activation of the EGF receptor by insertional mutations in its juxtamembrane regions. (Sorokin A) Oncogene 1995 Oct 19;11(8):1531-40 30 Citations |
| 1 | Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. (Moyer JH, Lee-Tischler MJ, Kwon HY, Schrick JJ, Avner ED, Sweeney WE, Godfrey VL, Cacheiro NL, Wilkinson JE, Woychik RP) Science 1994 May 27;264(5163):1329-33 330 Citations |
| 1 | Construction and characterization of chromosomal insertional mutations of the Pseudomonas aeruginosa exoenzyme S trans-regulatory locus. (Frank DW, Nair G, Schweizer HP) Infect Immun 1994 Feb;62(2):554-63 68 Citations |
| 1 | Start site selection at the TATA-less carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase promoter. (Kollmar R, Sukow KA, Sponagle SK, Farnham PJ) J Biol Chem 1994 Jan 21;269(3):2252-7 74 Citations |
| 1 | Renal developmental diseases. (Avner ED) Semin Nephrol 1993 Sep;13(5):427-35 15 Citations |
