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Publications indexed to the term Telomerase

FacultyTitle
1Autophagy modulates the mechanism of flow-mediated dilation upstream of telomerase. (Hughes WE, Hader SN, Astbury K, Brandt L, Ait-Aissa K, Gutterman DD, Beyer AM) Basic Res Cardiol 2025 Dec;120(6):1131-1140    
1Endothelial TERT drives microvascular phenotype associated with coronary artery disease. (Birch EC, Nishijima Y, Hader SN, Beyer AM) Am J Physiol Heart Circ Physiol 2025 Jul 01;329(1):H267-H270    
1Comprehensive Molecular Analysis in NRG Oncology/RTOG 9813: A Phase 3 Study of Radiation and Temozolomide Versus Radiation and BCNU/CCNU in Anaplastic Astrocytoma. (Fleming JL, Pugh SL, Chang SM, McElroy JP, Becker AP, Aldape KD, Shih HA, Ashby LS, Hunter GK, Bahary JP, Schultz CJ, Kavanagh BD, Puduvalli VK, Robins HI, Werner-Wasik M, Mehta M, Chakravarti A) Int J Radiat Oncol Biol Phys 2025 Sep 01;123(1):84-92       2 Citations
2Mesenchymal-Type Genetic Mutations Are Likely Prerequisite for Glioblastoma Multiforme to Metastasize Outside the Central Nervous System: An Original Case Series and Systematic Review of the Literature. (Laurin BJ, Treffy R, Connelly JM, Straza M, Mueller WM, Krucoff MO) World Neurosurg 2025 Jan;193:397-426       3 Citations
1Determinants of mosaic chromosomal alteration fitness. (Pershad Y, Mack T, Poisner H, Jakubek YA, Stilp AM, Mitchell BD, Lewis JP, Boerwinkle E, Loos RJF, Chami N, Wang Z, Barnes K, Pankratz N, Fornage M, Redline S, Psaty BM, Bis JC, Shojaie A, Silverman EK, Cho MH, Yun JH, DeMeo D, Levy D, Johnson AD, Mathias RA, Taub MA, Arnett D, North KE, Raffield LM, Carson AP, Doyle MF, Rich SS, Rotter JI, Guo X, Cox NJ, Roden DM, Franceschini N, Desai P, Reiner AP, Auer PL, Scheet PA, Jaiswal S, Weinstock JS, Bick AG) Nat Commun 2024 May 07;15(1):3800       6 Citations
1The role of telomerase reverse transcriptase in the mitochondrial protective functions of Angiotensin-(1-7) in diabetic CD34+ cells. (Jahan J, Joshi S, Oca IM, Toelle A, Lopez-Yang C, Chacon CV, Beyer AM, Garcia CA, Jarajapu YP) Biochem Pharmacol 2024 Apr;222:116109       7 Citations
1Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR. (Wang Y, He Y, Wang Y, Yang Y, Singh M, Eichhorn CD, Cheng X, Jiang YX, Zhou ZH, Feigon J) J Mol Biol 2023 Jun 01;435(11):168044       9 Citations
3Noncanonical Role of Telomerase in Regulation of Microvascular Redox Environment With Implications for Coronary Artery Disease. (Ait-Aissa K, Norwood-Toro LE, Terwoord J, Young M, Paniagua LA, Hader SN, Hughes WE, Hockenberry JC, Beare JE, Linn J, Kohmoto T, Kim J, Betts DH, LeBlanc AJ, Gutterman DD, Beyer AM) Function (Oxf) 2022;3(5):zqac043       15 Citations
1Structure of Tetrahymena telomerase-bound CST with polymerase α-primase. (He Y, Song H, Chan H, Liu B, Wang Y, Sušac L, Zhou ZH, Feigon J) Nature 2022 Aug;608(7924):813-818       33 Citations
1Structure of active human telomerase with telomere shelterin protein TPP1. (Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J) Nature 2022 Apr;604(7906):578-583       89 Citations
4Autophagy, TERT, and mitochondrial dysfunction in hyperoxia. (Beyer AM, Norwood Toro LE, Hughes WE, Young M, Clough AV, Gao F, Medhora M, Audi SH, Jacobs ER) Am J Physiol Heart Circ Physiol 2021 Nov 01;321(5):H985-H1003       32 Citations
1The clinical and functional effects of TERT variants in myelodysplastic syndrome. (Reilly CR, Myllymäki M, Redd R, Padmanaban S, Karunakaran D, Tesmer V, Tsai FD, Gibson CJ, Rana HQ, Zhong L, Saber W, Spellman SR, Hu ZH, Orr EH, Chen MM, De Vivo I, DeAngelo DJ, Cutler C, Antin JH, Neuberg D, Garber JE, Nandakumar J, Agarwal S, Lindsley RC) Blood 2021 Sep 09;138(10):898-911       46 Citations
1Structures of telomerase at several steps of telomere repeat synthesis. (He Y, Wang Y, Liu B, Helmling C, Sušac L, Cheng R, Zhou ZH, Feigon J) Nature 2021 May;593(7859):454-459       58 Citations
1A structurally conserved human and Tetrahymena telomerase catalytic core. (Wang Y, Gallagher-Jones M, Sušac L, Song H, Feigon J) Proc Natl Acad Sci U S A 2020 Dec 08;117(49):31078-31087       23 Citations
3Critical Interaction Between Telomerase and Autophagy in Mediating Flow-Induced Human Arteriolar Vasodilation. (Hughes WE, Chabowski DS, Ait-Aissa K, Fetterman JL, Hockenberry J, Beyer AM, Gutterman DD) Arterioscler Thromb Vasc Biol 2021 Jan;41(1):446-457       21 Citations
1Functional validation of TERT and TERC variants of uncertain significance in patients with short telomere syndromes. (Ferrer A, Mangaonkar AA, Stroik S, Zimmermann MT, Sigafoos AN, Kamath PS, Simonetto DA, Wylam ME, Carmona EM, Lazaridis KN, Peters S, Stewart K, Klee EW, Hendrickson EA, Patnaik MM) Blood Cancer J 2020 Nov 17;10(11):120       8 Citations
2Pan-cancer analysis of whole genomes. (ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium) Nature 2020 Feb;578(7793):82-93       2329 Citations
2The landscape of viral associations in human cancers. (Zapatka M, Borozan I, Brewer DS, Iskar M, Grundhoff A, Alawi M, Desai N, Sültmann H, Moch H, PCAWG Pathogens, Cooper CS, Eils R, Ferretti V, Lichter P, PCAWG Consortium) Nat Genet 2020 Mar;52(3):320-330       319 Citations
2Patterns of somatic structural variation in human cancer genomes. (Li Y, Roberts ND, Wala JA, Shapira O, Schumacher SE, Kumar K, Khurana E, Waszak S, Korbel JO, Haber JE, Imielinski M, PCAWG Structural Variation Working Group, Weischenfeldt J, Beroukhim R, Campbell PJ, PCAWG Consortium) Nature 2020 Feb;578(7793):112-121       605 Citations
2Genomic footprints of activated telomere maintenance mechanisms in cancer. (Sieverling L, Hong C, Koser SD, Ginsbach P, Kleinheinz K, Hutter B, Braun DM, Cortés-Ciriano I, Xi R, Kabbe R, Park PJ, Eils R, Schlesner M, PCAWG-Structural Variation Working Group, Brors B, Rippe K, Jones DTW, Feuerbach L, PCAWG Consortium) Nat Commun 2020 Feb 05;11(1):733       107 Citations
1Structural Biology of Telomerase. (Wang Y, Sušac L, Feigon J) Cold Spring Harb Perspect Biol 2019 Dec 02;11(12)       77 Citations
1The role of TERT promoter mutations in differentiating recurrent nevi from recurrent melanomas: A retrospective, case-control study. (Walton KE, Garfield EM, Zhang B, Quan VL, Shi K, Mohan LS, Haugh AM, VandenBoom T, Yazdan P, Isales MC, Panah E, Gerami P) J Am Acad Dermatol 2019 Mar;80(3):685-693       13 Citations
1Short telomere syndromes cause a primary T cell immunodeficiency. (Wagner CL, Hanumanthu VS, Talbot CC Jr, Abraham RS, Hamm D, Gable DL, Kanakry CG, Applegate CD, Siliciano J, Jackson JB, Desiderio S, Alder JK, Luznik L, Armanios M) J Clin Invest 2018 Dec 03;128(12):5222-5234       108 Citations
1Telomerase: Location, Location, Location? (Beyer AM, Norwood Toro LE) Arterioscler Thromb Vasc Biol 2018 Jun;38(6):1247-1249       4 Citations
1Structure of Telomerase with Telomeric DNA. (Jiang J, Wang Y, Sušac L, Chan H, Basu R, Zhou ZH, Feigon J) Cell 2018 May 17;173(5):1179-1190.e13       127 Citations
1Chemotherapeutic-Induced Cardiovascular Dysfunction: Physiological Effects, Early Detection-The Role of Telomerase to Counteract Mitochondrial Defects and Oxidative Stress. (Quryshi N, Norwood Toro LE, Ait-Aissa K, Kong A, Beyer AM) Int J Mol Sci 2018 Mar 10;19(3)       24 Citations
2Telomerase reverse transcriptase protects against angiotensin II-induced microvascular endothelial dysfunction. (Ait-Aissa K, Kadlec AO, Hockenberry J, Gutterman DD, Beyer AM) Am J Physiol Heart Circ Physiol 2018 May 01;314(5):H1053-H1060       33 Citations
1Telomerase reverse transcriptase promoter alterations across cancer types as detected by next-generation sequencing: A clinical and molecular analysis of 423 patients. (Schwaederle M, Krishnamurthy N, Daniels GA, Piccioni DE, Kesari S, Fanta PT, Schwab RB, Patel SP, Parker BA, Kurzrock R) Cancer 2018 Mar 15;124(6):1288-1296       26 Citations
1Structural biology of telomerase and its interaction at telomeres. (Wang Y, Feigon J) Curr Opin Struct Biol 2017 Dec;47:77-87       27 Citations
1Fine mapping of chromosome 5p15.33 identifies novel lung cancer susceptibility loci in Han Chinese. (Dong J, Cheng Y, Zhu M, Wen Y, Wang C, Wang Y, Geng L, Shen W, Liu J, Li Z, Zhang J, Ma H, Dai J, Jin G, Hu Z, Shen H) Int J Cancer 2017 Aug 01;141(3):447-456       19 Citations
1Progress in Human and Tetrahymena Telomerase Structure Determination. (Chan H, Wang Y, Feigon J) Annu Rev Biophys 2017 May 22;46:199-225       40 Citations
1Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human. (Wang Y, Yesselman JD, Zhang Q, Kang M, Feigon J) Proc Natl Acad Sci U S A 2016 Aug 30;113(35):E5125-34       26 Citations
1Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema. (Stanley SE, Gable DL, Wagner CL, Carlile TM, Hanumanthu VS, Podlevsky JD, Khalil SE, DeZern AE, Rojas-Duran MF, Applegate CD, Alder JK, Parry EM, Gilbert WV, Armanios M) Sci Transl Med 2016 Aug 10;8(351):351ra107       185 Citations
1Friend or foe? Telomerase as a pharmacological target in cancer and cardiovascular disease. (Ait-Aissa K, Ebben JD, Kadlec AO, Beyer AM) Pharmacol Res 2016 Sep;111:422-433       31 Citations
5Vascular Actions of Angiotensin 1-7 in the Human Microcirculation: Novel Role for Telomerase. (Durand MJ, Zinkevich NS, Riedel M, Gutterman DD, Nasci VL, Salato VK, Hijjawi JB, Reuben CF, North PE, Beyer AM) Arterioscler Thromb Vasc Biol 2016 Jun;36(6):1254-62       60 Citations
5Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. (Beyer AM, Freed JK, Durand MJ, Riedel M, Ait-Aissa K, Green P, Hockenberry JC, Morgan RG, Donato AJ, Peleg R, Gasparri M, Rokkas CK, Santos JH, Priel E, Gutterman DD) Circ Res 2016 Mar 04;118(5):856-66       98 Citations
1Lung transplantation in telomerase mutation carriers with pulmonary fibrosis. (Silhan LL, Shah PD, Chambers DC, Snyder LD, Riise GC, Wagner CL, Hellström-Lindberg E, Orens JB, Mewton JF, Danoff SK, Arcasoy MO, Armanios M) Eur Respir J 2014 Jul;44(1):178-87       179 Citations
1Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery. (Guan X, Mack DL, Moreno CM, Strande JL, Mathieu J, Shi Y, Markert CD, Wang Z, Liu G, Lawlor MW, Moorefield EC, Jones TN, Fugate JA, Furth ME, Murry CE, Ruohola-Baker H, Zhang Y, Santana LF, Childers MK) Stem Cell Res 2014 Mar;12(2):467-80       121 Citations
1Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs. (Winkler T, Hong SG, Decker JE, Morgan MJ, Wu C, Hughes WM 5th, Yang Y, Wangsa D, Padilla-Nash HM, Ried T, Young NS, Dunbar CE, Calado RT) J Clin Invest 2013 May;123(5):1952-63       63 Citations
1Occult tumour cells in peritoneal lavage are a negative prognostic factor in pancreatic cancer. (Havlik R, Srovnal J, Klos D, Benedikova A, Lovecek M, Ghothim M, Cahova D, Neoral C, Hajduch M) Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2013 Sep;157(3):233-8       9 Citations
1Human telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step. (Steczkiewicz K, Zimmermann MT, Kurcinski M, Lewis BA, Dobbs D, Kloczkowski A, Jernigan RL, Kolinski A, Ginalski K) Proc Natl Acad Sci U S A 2011 Jun 07;108(23):9443-8       46 Citations
1Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke. (Zhang B, Chen L, Swartz KR, Bruemmer D, Eum SY, Huang W, Seelbach M, Choi YJ, Hennig B, Toborek M) J Neurosci Res 2010 Oct;88(13):2859-68       34 Citations
1Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB. (Rafiee P, Nelson VM, Manley S, Wellner M, Floer M, Binion DG, Shaker R) Am J Physiol Gastrointest Liver Physiol 2009 Feb;296(2):G388-98       89 Citations
1Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene. (Du HY, Pumbo E, Manley P, Field JJ, Bayliss SJ, Wilson DB, Mason PJ, Bessler M) Blood 2008 Feb 01;111(3):1128-30       53 Citations
1Low frequency of telomerase RNA mutations among children with aplastic anemia or myelodysplastic syndrome. (Field JJ, Mason PJ, An P, Kasai Y, McLellan M, Jaeger S, Barnes YJ, King AA, Bessler M, Wilson DB) J Pediatr Hematol Oncol 2006 Jul;28(7):450-3       27 Citations
1Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR. (Bais C, Van Geelen A, Eroles P, Mutlu A, Chiozzini C, Dias S, Silverstein RL, Rafii S, Mesri EA) Cancer Cell 2003 Feb;3(2):131-43       222 Citations
1Expression of human telomerase reverse transcriptase, the catalytic subunit of telomerase, is associated with the development of persistent disease in complete hydatidiform moles. (Amezcua CA, Bahador A, Naidu YM, Felix JC) Am J Obstet Gynecol 2001 Jun;184(7):1441-6       8 Citations
1mTert expression correlates with telomerase activity during the differentiation of murine embryonic stem cells. (Armstrong L, Lako M, Lincoln J, Cairns PM, Hole N) Mech Dev 2000 Oct;97(1-2):109-16       106 Citations
1The detection of telomerase activity in patients with adenocarcinoma of the pancreas by fine needle aspiration. (Pearson AS, Chiao P, Zhang L, Zhang W, Larry L, Katz RL, Evans DB, Abbruzzese JL) Int J Oncol 2000 Aug;17(2):381-5       38 Citations
1Telomerase activity in benign and malignant epithelial ovarian tumors. (Wan M, Li WZ, Duggan BD, Felix JC, Zhao Y, Dubeau L) J Natl Cancer Inst 1997 Mar 19;89(6):437-41       51 Citations