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Publications indexed to the term Graft vs Leukemia Effect

FacultyTitle
1The druggable transcription factor Fli-1 regulates T cell immunity and tolerance in graft-versus-host disease. (Schutt SD, Wu Y, Kharel A, Bastian D, Choi HJ, Hanief Sofi M, Mealer C, McDaniel Mims B, Nguyen H, Liu C, Helke K, Cui W, Zhang X, Ben-David Y, Yu XZ) J Clin Invest 2022 Nov 01;132(21)       5 Citations
1Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK pathway. (Sofi MH, Tian L, Schutt S, Khan I, Choi HJ, Wu Y, Bastian D, Ticer T, Kassir MF, Atilgan FC, Kim J, Sui X, Zivkovic A, Mehrotra S, O'Bryan JP, Stark H, Martin PJ, Ogretmen B, Yu XZ) Leukemia 2022 Jul;36(7):1907-1915       8 Citations
1A single strain of Bacteroides fragilis protects gut integrity and reduces GVHD. (Sofi MH, Wu Y, Ticer T, Schutt S, Bastian D, Choi HJ, Tian L, Mealer C, Liu C, Westwater C, Armeson KE, Alekseyenko AV, Yu XZ) JCI Insight 2021 Feb 08;6(3)       42 Citations
3Kras-Deficient T Cells Attenuate Graft-versus-Host Disease but Retain Graft-versus-Leukemia Activity. (Luo L, Chen Y, Chen X, Zheng Y, Zhou V, Yu M, Burns R, Zhu W, Fu G, Felix JC, Hartley C, Damnernsawad A, Zhang J, Wen R, Drobyski WR, Gao C, Wang D) J Immunol 2020 Dec 15;205(12):3480-3490       3 Citations
2Single-center experience suggests donor lymphocyte infusion may promote long-term survival in children with high-risk acute lymphoblastic leukemia. (Liberio N, Robinson H, Nugent M, Simpson P, Margolis DA, Malarkannan S, Keever-Taylor C, Thakar MS) Pediatr Blood Cancer 2019 Nov;66(11):e27950       8 Citations
3The impact of the graft-versus-leukemia effect on survival in acute lymphoblastic leukemia. (Yeshurun M, Weisdorf D, Rowe JM, Tallman MS, Zhang MJ, Wang HL, Saber W, de Lima M, Sandmaier BM, Uy G, Kamble RT, Cairo MS, Cooper BW, Cahn JY, Ganguly S, Camitta B, Verdonck LF, Dandoy C, Diaz MA, Savani BN, George B, Liesveld J, McGuirk J, Byrne M, Grunwald MR, Drobyski WR, Pulsipher MA, Abdel-Azim H, Prestidge T, Wieduwilt MJ, Martino R, Norkin M, Beitinjaneh A, Seo S, Nishihori T, Wirk B, Frangoul H, Bashey A, Mori S, Marks DI, Bachanova V) Blood Adv 2019 Feb 26;3(4):670-680       57 Citations
1Donor Killer Cell Immunoglobulin-Like Receptor Genotype Does Not Improve Graft-versus-Leukemia Responses in Chronic Lymphocytic Leukemia after Unrelated Donor Transplant: A Center for International Blood and Marrow Transplant Research Analysis. (Bachanova V, Weisdorf DJ, Wang T, Marsh SGE, Cereb N, Haagenson MD, Spellman SR, Lee SJ, Guethlein LA, Parham P, Miller JS, Cooley SA) Biol Blood Marrow Transplant 2019 May;25(5):949-954       8 Citations
1Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice. (Daenthanasanmak A, Iamsawat S, Chakraborty P, Nguyen HD, Bastian D, Liu C, Mehrotra S, Yu XZ) Blood 2019 Jan 17;133(3):266-279       58 Citations
1Stabilization of Foxp3 by Targeting JAK2 Enhances Efficacy of CD8 Induced Regulatory T Cells in the Prevention of Graft-versus-Host Disease. (Iamsawat S, Daenthanasanmak A, Voss JH, Nguyen H, Bastian D, Liu C, Yu XZ) J Immunol 2018 Nov 01;201(9):2812-2823       26 Citations
1Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice. (Schutt SD, Wu Y, Tang CH, Bastian D, Nguyen H, Sofi MH, Zhang M, Liu C, Helke K, Wilson C, Schnapp LM, Del Valle JR, Hu CC, Yu XZ) Blood Adv 2018 Feb 27;2(4):414-427       17 Citations
1Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation. (Betts BC, Bastian D, Iamsawat S, Nguyen H, Heinrichs JL, Wu Y, Daenthanasanmak A, Veerapathran A, O'Mahony A, Walton K, Reff J, Horna P, Sagatys EM, Lee MC, Singer J, Chang YJ, Liu C, Pidala J, Anasetti C, Yu XZ) Proc Natl Acad Sci U S A 2018 Feb 13;115(7):1582-1587       58 Citations
1T-bet Promotes Acute Graft-versus-Host Disease by Regulating Recipient Hematopoietic Cells in Mice. (Fu J, Wu Y, Nguyen H, Heinrichs J, Schutt S, Liu Y, Liu C, Jin J, Anasetti C, Yu XZ) J Immunol 2016 Apr 01;196(7):3168-79       6 Citations
1MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice. (Wu Y, Heinrichs J, Bastian D, Fu J, Nguyen H, Schutt S, Liu Y, Jin J, Liu C, Li QJ, Xia C, Yu XZ) Blood 2015 Sep 10;126(11):1314-23       53 Citations
1HY-Specific Induced Regulatory T Cells Display High Specificity and Efficacy in the Prevention of Acute Graft-versus-Host Disease. (Li J, Heinrichs J, Haarberg K, Semple K, Veerapathran A, Liu C, Anasetti C, Yu XZ) J Immunol 2015 Jul 15;195(2):717-25       22 Citations
1Essential Role of Interleukin-12/23p40 in the Development of Graft-versus-Host Disease in Mice. (Wu Y, Bastian D, Schutt S, Nguyen H, Fu J, Heinrichs J, Xia C, Yu XZ) Biol Blood Marrow Transplant 2015 Jul;21(7):1195-204       22 Citations
1Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice. (Haarberg KM, Li J, Heinrichs J, Wang D, Liu C, Bronk CC, Kaosaard K, Owyang AM, Holland S, Masuda E, Tso K, Blazar BR, Anasetti C, Beg AA, Yu XZ) Blood 2013 Oct 03;122(14):2500-11       35 Citations
1Evidence for a GVL effect following reduced-intensity allo-SCT in ALL: a British Society of Blood and Marrow Transplantation study. (Medd PG, Peniket AJ, Littlewood TJ, Pearce R, Perry J, Kirkland KE, Shaw BE, Potter MN, Craddock CF, Milligan DW, Fielding AK, Marks DI, Cook G, British Society of Blood and Marrow Transplantation) Bone Marrow Transplant 2013 Jul;48(7):982-7       10 Citations
4Graft-versus-host disease induced graft-versus-leukemia effect: greater impact on relapse and disease-free survival after reduced intensity conditioning. (Weisdorf D, Zhang MJ, Arora M, Horowitz MM, Rizzo JD, Eapen M) Biol Blood Marrow Transplant 2012 Nov;18(11):1727-33       115 Citations
1Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice. (Yu Y, Wang D, Liu C, Kaosaard K, Semple K, Anasetti C, Yu XZ) Blood 2011 Nov 03;118(18):5011-20       133 Citations
2Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses. (Das R, Komorowski R, Hessner MJ, Subramanian H, Huettner CS, Cua D, Drobyski WR) Blood 2010 Jun 24;115(25):5249-58       45 Citations
1PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. (Valenzuela JO, Iclozan C, Hossain MS, Prlic M, Hopewell E, Bronk CC, Wang J, Celis E, Engelman RW, Blazar BR, Bevan MJ, Waller EK, Yu XZ, Beg AA) J Clin Invest 2009 Dec;119(12):3774-86       66 Citations
1Sibling versus unrelated donor allogeneic hematopoietic cell transplantation for chronic myelogenous leukemia: refined HLA matching reveals more graft-versus-host disease but not less relapse. (Weisdorf DJ, Nelson G, Lee SJ, Haagenson M, Spellman S, Antin JH, Bolwell B, Cahn JY, Cervantes F, Copelan E, Gale R, Gratwohl A, Khoury HJ, McCarthy P, Marks DI, Szer J, Woolfrey A, Cortes-Franco J, Horowitz MM, Arora M, Chronic Leukemia Working Committee) Biol Blood Marrow Transplant 2009 Nov;15(11):1475-8       36 Citations
1Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units. (Verneris MR, Brunstein CG, Barker J, MacMillan ML, DeFor T, McKenna DH, Burke MJ, Blazar BR, Miller JS, McGlave PB, Weisdorf DJ, Wagner JE) Blood 2009 Nov 05;114(19):4293-9       238 Citations
2The graft-versus-leukemia effect using matched unrelated donors is not superior to HLA-identical siblings for hematopoietic stem cell transplantation. (Ringdén O, Pavletic SZ, Anasetti C, Barrett AJ, Wang T, Wang D, Antin JH, Di Bartolomeo P, Bolwell BJ, Bredeson C, Cairo MS, Gale RP, Gupta V, Hahn T, Hale GA, Halter J, Jagasia M, Litzow MR, Locatelli F, Marks DI, McCarthy PL, Cowan MJ, Petersdorf EW, Russell JA, Schiller GJ, Schouten H, Spellman S, Verdonck LF, Wingard JR, Horowitz MM, Arora M) Blood 2009 Mar 26;113(13):3110-8       138 Citations
1Hematopoietic stem cell transplantation in adults with acute myeloid leukemia. (Hamadani M, Awan FT, Copelan EA) Biol Blood Marrow Transplant 2008 May;14(5):556-67       37 Citations
1CD3+ cell dose and disease status are important factors determining clinical outcomes in patients undergoing unmanipulated haploidentical blood and marrow transplantation after conditioning including antithymocyte globulin. (Dong L, Wu T, Zhang MJ, Gao ZY, Lu DP) Biol Blood Marrow Transplant 2007 Dec;13(12):1515-24       33 Citations
1Beta2 integrins separate graft-versus-host disease and graft-versus-leukemia effects. (Liang Y, Liu C, Djeu JY, Zhong B, Peters T, Scharffetter-Kochanek K, Anasetti C, Yu XZ) Blood 2008 Jan 15;111(2):954-62       44 Citations
1The impact of chimerism patterns and predonor leukocyte infusion lymphopenia on survival following T cell-depleted reduced intensity conditioned transplants. (Shaw BE, Byrne JL, Das-Gupta E, Carter GI, Russell NH) Biol Blood Marrow Transplant 2007 May;13(5):550-9       25 Citations
2Recent molecular and cellular advances in pediatric bone marrow transplantation. (Talano JA, Margolis DA) Pediatr Clin North Am 2006 Aug;53(4):685-98       2 Citations
1Graft-versus-leukemia and graft-versus-host reactions after donor lymphocyte infusion are initiated by host-type antigen-presenting cells and regulated by regulatory T cells in early and long-term chimeras. (Xia G, Truitt RL, Johnson BD) Biol Blood Marrow Transplant 2006 Apr;12(4):397-407       57 Citations
3Temporal discordance between graft-versus-leukemia and graft-versus-host responses: a strategy for the separation of graft-versus-leukemia/graft-versus-host reactivity? (Hari P, Logan B, Drobyski WR) Biol Blood Marrow Transplant 2004 Nov;10(11):743-7       9 Citations
1In-vivo generation of leukaemia-derived dendritic cells. (Kolb HJ, Rank A, Chen X, Woiciechowsky A, Roskrow M, Schmid C, Tischer J, Ledderose G) Best Pract Res Clin Haematol 2004 Sep;17(3):439-51       18 Citations
1Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions. (Burt RK, Drobyski WR, Seregina T, Traynor A, Oyama Y, Keever-Taylor C, Stefka J, Kuzel TM, Brush M, Rodriquez J, Burns W, Tennant L, Link C) Exp Hematol 2003 Oct;31(10):903-10       42 Citations
1Elimination of leukemia in the absence of lethal graft-versus-host disease after allogenic bone marrow transplantation. (Drobyski WR, Gendelman M, Vodanovic-Jankovic S, Gorski J) J Immunol 2003 Mar 15;170(6):3046-53       16 Citations
1Donor natural killer (NK1.1+) cells do not play a role in the suppression of GVHD or in the mediation of GVL reactions after DLI. (Johnson BD, Dagher N, Stankowski WC, Hanke CA, Truitt RL) Biol Blood Marrow Transplant 2001;7(11):589-95       11 Citations
1In vitro T-cell receptor V beta repertoire analysis may identify which T-cell V beta families mediate graft-versus-leukaemia and graft-versus-host responses after human leucocyte antigen-matched sibling stem cell transplantation. (Epperson DE, Margolis DA, McOlash L, Janczak T, Barrett AJ) Br J Haematol 2001 Jul;114(1):57-62       18 Citations