| 1 | ESCRT-III assembles around mis-segregated DNA to protect genome stability. (Glover J, Talledge N, McCullough J, Alian A, Sadler JBA, Kamboj S, Dempsey NWM, Laughlin TG, Nguyen HC, Wenzel DM, Lalonde MS, Paine EL, Ganser-Pornillos B, Ventimiglia LN, LaJoie D, Iwasa JH, Arthur CP, Lee DJ, Moss FR 3rd, Venkatesh M, Arnold LM, Johnson JS, Ullman KS, Frost A, Sundquist WI, Martin-Serrano J) Nat Struct Mol Biol 2026 Aug;33(8):1236-1251 1 Citation |
| 1 | Variants in GCNA, X-linked germ-cell genome integrity gene, identified in men with primary spermatogenic failure. (Hardy JJ, Wyrwoll MJ, Mcfadden W, Malcher A, Rotte N, Pollock NC, Munyoki S, Veroli MV, Houston BJ, Xavier MJ, Kasak L, Punab M, Laan M, Kliesch S, Schlegel P, Jaffe T, Hwang K, Vukina J, Brieño-Enríquez MA, Orwig K, Yanowitz J, Buszczak M, Veltman JA, Oud M, Nagirnaja L, Olszewska M, O'Bryan MK, Conrad DF, Kurpisz M, Tüttelmann F, Yatsenko AN, GEMINI Consortium) Hum Genet 2021 Aug;140(8):1169-1182 30 Citations |
| 2 | Sex differences in oncogenic mutational processes. (Li CH, Prokopec SD, Sun RX, Yousif F, Schmitz N, PCAWG Tumour Subtypes and Clinical Translation, Boutros PC, PCAWG Consortium) Nat Commun 2020 Aug 28;11(1):4330 88 Citations |
| 1 | Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program. (Kanchan K, Iyer K, Yanek LR, Carcamo-Orive I, Taub MA, Malley C, Baldwin K, Becker LC, Broeckel U, Cheng L, Cowan C, D'Antonio M, Frazer KA, Quertermous T, Mostoslavsky G, Murphy G, Rabinovitch M, Rader DJ, Steinberg MH, Topol E, Yang W, Knowles JW, Jaquish CE, Ruczinski I, Mathias RA) Stem Cell Res 2020 Jul;46:101803 13 Citations |
| 1 | Variability in retinoblastoma genome stability is driven by age and not heritability. (Polski A, Xu L, Prabakar RK, Gai X, Kim JW, Shah R, Jubran R, Kuhn P, Cobrinik D, Hicks J, Berry JL) Genes Chromosomes Cancer 2020 Oct;59(10):584-590 24 Citations |
| 1 | BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells. (Zhang X, Wang Y, Chiang HC, Hsieh YP, Lu C, Park BH, Jatoi I, Jin VX, Hu Y, Li R) Breast Cancer Res 2019 Apr 17;21(1):51 21 Citations |
| 1 | A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability. (Sadler JBA, Wenzel DM, Strohacker LK, Guindo-Martínez M, Alam SL, Mercader JM, Torrents D, Ullman KS, Sundquist WI, Martin-Serrano J) Proc Natl Acad Sci U S A 2018 Sep 18;115(38):E8900-E8908 59 Citations |
| 2 | Stromal PTEN determines mammary epithelial response to radiotherapy. (Sizemore GM, Balakrishnan S, Thies KA, Hammer AM, Sizemore ST, Trimboli AJ, Cuitiño MC, Steck SA, Tozbikian G, Kladney RD, Shinde N, Das M, Park D, Majumder S, Krishnan S, Yu L, Fernandez SA, Chakravarti A, Shields PG, White JR, Yee LD, Rosol TJ, Ludwig T, Park M, Leone G, Ostrowski MC) Nat Commun 2018 Jul 17;9(1):2783 24 Citations |
| 1 | Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer. (Wu YM, Cieślik M, Lonigro RJ, Vats P, Reimers MA, Cao X, Ning Y, Wang L, Kunju LP, de Sarkar N, Heath EI, Chou J, Feng FY, Nelson PS, de Bono JS, Zou W, Montgomery B, Alva A, PCF/SU2C International Prostate Cancer Dream Team, Robinson DR, Chinnaiyan AM) Cell 2018 Jun 14;173(7):1770-1782.e14 523 Citations |
| 1 | Application of RNAi-induced gene expression profiles for prognostic prediction in breast cancer. (Wang Y, Mark KM, Ung MH, Kettenbach A, Miller T, Xu W, Cheng W, Xia T, Cheng C) Genome Med 2016 Oct 27;8(1):114 3 Citations |
| 1 | Universal Genomic Testing Needed to Win the War Against Cancer: Genomics IS the Diagnosis. (Subbiah V, Kurzrock R) JAMA Oncol 2016 Jun 01;2(6):719-20 43 Citations |
| 1 | Genetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes From a Subset of Patients With Familial Colorectal Carcinomas. (Arora S, Yan H, Cho I, Fan HY, Luo B, Gai X, Bodian DL, Vockley JG, Zhou Y, Handorf EA, Egleston BL, Andrake MD, Nicolas E, Serebriiskii IG, Yen TJ, Hall MJ, Golemis EA, Enders GH) Gastroenterology 2015 Dec;149(7):1872-1883.e9 31 Citations |
| 1 | Fhit deficiency-induced global genome instability promotes mutation and clonal expansion. (Miuma S, Saldivar JC, Karras JR, Waters CE, Paisie CA, Wang Y, Jin V, Sun J, Druck T, Zhang J, Huebner K) PLoS One 2013;8(11):e80730 29 Citations |
| 1 | Penetrance and expressivity of MSH6 germline mutations in seven kindreds not ascertained by family history. (Buttin BM, Powell MA, Mutch DG, Babb SA, Huettner PC, Edmonston TB, Herzog TJ, Rader JS, Gibb RK, Whelan AJ, Goodfellow PJ) Am J Hum Genet 2004 Jun;74(6):1262-9 59 Citations |
| 1 | Elevated presence of retrotransposons at sites of DNA double strand break repair in mouse models of metabolic oxidative stress and MYC-induced lymphoma. (Rockwood LD, Felix K, Janz S) Mutat Res 2004 Apr 14;548(1-2):117-25 23 Citations |