1 | DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells. (Wang Y, Han D, Zhou T, Chen C, Cao H, Zhang JZ, Ma N, Liu C, Song M, Shi J, Jin X, Cao F, Dong N) Eur Heart J 2021 Aug 07;42(30):2935-2951 22 Citations |
1 | DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling. (Bogush N, Tan L, Naib H, Faizullabhoy E, Calvert JW, Iismaa SE, Gupta A, Ramchandran R, Martin DIK, Graham RM, Husain A, Naqvi N) Sci Rep 2020 Dec 14;10(1):21918 13 Citations |
1 | Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury. (Zhang C, He X, Murphy SR, Zhang H, Wang S, Ge Y, Gao W, Williams JM, Geurts AM, Roman RJ, Fan F) J Pharmacol Exp Ther 2019 Aug;370(2):206-217 16 Citations |
1 | Role of Conserved Histidine and Serine in the HCXXXXXRS Motif of Human Dual-Specificity Phosphatase 5. (Gupta A, Brahmbhatt J, Syrlybaeva R, Bodnar C, Bodnar N, Bongard R, Pokkuluri PR, Sem DS, Ramchandran R, Rathore R, Talipov MR) J Chem Inf Model 2019 Apr 22;59(4):1563-1574 1 Citation |
1 | Dual Specificity Phosphatase 5-Substrate Interaction: A Mechanistic Perspective. (Kutty RG, Talipov MR, Bongard RD, Lipinski RAJ, Sweeney NL, Sem DS, Rathore R, Ramchandran R) Compr Physiol 2017 Sep 12;7(4):1449-1461 15 Citations |
1 | Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor. (Bongard RD, Lepley M, Thakur K, Talipov MR, Nayak J, Lipinski RAJ, Bohl C, Sweeney N, Ramchandran R, Rathore R, Sem DS) BMC Biochem 2017 May 31;18(1):10 7 Citations |
1 | Dual Specificity Phosphatase 5 Is Essential for T Cell Survival. (Kutty RG, Xin G, Schauder DM, Cossette SM, Bordas M, Cui W, Ramchandran R) PLoS One 2016;11(12):e0167246 15 Citations |
1 | Critical Role of the Secondary Binding Pocket in Modulating the Enzymatic Activity of DUSP5 toward Phosphorylated ERKs. (Talipov MR, Nayak J, Lepley M, Bongard RD, Sem DS, Ramchandran R, Rathore R) Biochemistry 2016 Nov 08;55(44):6187-6195 5 Citations |
1 | Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets. (Neumann TS, Span EA, Kalous KS, Bongard R, Gastonguay A, Lepley MA, Kutty RG, Nayak J, Bohl C, Lange RG, Sarker MI, Talipov MR, Rathore R, Ramchandran R, Sem DS) BMC Biochem 2015 Aug 19;16:19 8 Citations |
1 | Protein expression, characterization and activity comparisons of wild type and mutant DUSP5 proteins. (Nayak J, Gastonguay AJ, Talipov MR, Vakeel P, Span EA, Kalous KS, Kutty RG, Jensen DR, Pokkuluri PR, Sem DS, Rathore R, Ramchandran R) BMC Biochem 2014 Dec 18;15:27 10 Citations |
1 | Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. (Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ) PLoS One 2014;9(11):e112878 31 Citations |
1 | Activation of MAPK pathways due to DUSP4 loss promotes cancer stem cell-like phenotypes in basal-like breast cancer. (Balko JM, Schwarz LJ, Bhola NE, Kurupi R, Owens P, Miller TW, Gómez H, Cook RS, Arteaga CL) Cancer Res 2013 Oct 15;73(20):6346-58 119 Citations |
1 | Role of dual-specificity protein phosphatase-5 in modulating the myogenic response in rat cerebral arteries. (Wickramasekera NT, Gebremedhin D, Carver KA, Vakeel P, Ramchandran R, Schuett A, Harder DR) J Appl Physiol (1985) 2013 Jan 15;114(2):252-61 9 Citations |
1 | Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance. (Balko JM, Cook RS, Vaught DB, Kuba MG, Miller TW, Bhola NE, Sanders ME, Granja-Ingram NM, Smith JJ, Meszoely IM, Salter J, Dowsett M, Stemke-Hale K, González-Angulo AM, Mills GB, Pinto JA, Gómez HL, Arteaga CL) Nat Med 2012 Jul;18(7):1052-9 211 Citations |
1 | Map kinase phosphatase 5 protects against sepsis-induced acute lung injury. (Qian F, Deng J, Gantner BN, Flavell RA, Dong C, Christman JW, Ye RD) Am J Physiol Lung Cell Mol Physiol 2012 May 01;302(9):L866-74 45 Citations |
3 | Dusp-5 and Snrk-1 coordinately function during vascular development and disease. (Pramanik K, Chun CZ, Garnaas MK, Samant GV, Li K, Horswill MA, North PE, Ramchandran R) Blood 2009 Jan 29;113(5):1184-91 57 Citations |
1 | ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cells. (Sarközi R, Miller B, Pollack V, Feifel E, Mayer G, Sorokin A, Schramek H) J Cell Physiol 2007 Apr;211(1):88-100 30 Citations |