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Mesh term Tumor Suppressor p53-Binding Protein 1

Browse to parent terms:
Chromosomal Proteins, Non-Histone
DNA-Binding Proteins

Description

A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.



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