Mesh term P-type ATPases
Browse to parent terms:Adenosine Triphosphatases
Membrane Transport Proteins
Description
A highly conserved family of ATPases that facilitate the transport of lipids and cations across the plasma membrane. Structurally, they are elongated ALPHA-HELICES constituting five functionally distinct domains: three cytoplasmic domains A, N, and P which contain the catalytic sites, and two transmembrane domains. The N domain phosphorylates the P-domain at an invariant ASPARTATE residue, which, in turn, is dephosphorylated by the A domain. The phosphorylation and dephosphorylation cycles drive conformational changes in the protein between two states (E1 and E2), which allow the substrate to access the other side of the membrane.Browse to child terms:
Calcium-Transporting ATPases
Copper-transporting ATPases
H(+)-K(+)-Exchanging ATPase
Sodium-Potassium-Exchanging ATPase
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