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Mesh term Mechanistic Target of Rapamycin Complex 1

Browse to parent terms:
Multiprotein Complexes
TOR Serine-Threonine Kinases

Description

An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.


Browse to child terms:
MTOR Associated Protein, LST8 Homolog
Regulatory-Associated Protein of mTOR


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