Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Mesh term Amyotrophic Lateral Sclerosis

Browse to parent terms:
Motor Neuron Disease
Spinal Cord Diseases
TDP-43 Proteinopathies

Description

A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)



Search for this term in our Faculty Database



View this term at the NCBI website