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Mesh term Cholesterol Side-Chain Cleavage Enzyme

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Cytochrome P450 Family 11
Steroid Hydroxylases

Description

A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.



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jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0