Mesh term Dactinomycin
Browse to parent terms:Heterocyclic Compounds, 3-Ring
Peptides, Cyclic
Description
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)Search for this term in our Faculty Database
View this term at the NCBI website
