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Mesh term MELAS Syndrome

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Brain Diseases, Metabolic, Inborn
Cerebral Small Vessel Diseases
Mitochondrial Encephalomyopathies

Description

A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)



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jenkins-FCD Prod-480 9a4deaf152b0b06dd18151814fff2e18f6c05280