Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Mesh term Receptor, IGF Type 1

Browse to parent terms:
Receptor Protein-Tyrosine Kinases
Receptors, Somatomedin

Description

A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.



Search for this term in our Faculty Database



View this term at the NCBI website