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Mesh term CD40 Antigens

Browse to parent terms:
Antigens, Differentiation, B-Lymphocyte
Receptors, Tumor Necrosis Factor

Description

Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.



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jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0