Mesh term eIF-2 Kinase
Browse to parent terms:Intracellular Signaling Peptides and Proteins
Protein-Serine-Threonine Kinases
Description
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.Search for this term in our Faculty Database
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