Mesh term STAT Transcription Factors
Browse to parent terms:Adaptor Proteins, Signal Transducing
Transcription Factors
Description
A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.Browse to child terms:
STAT1 Transcription Factor
STAT2 Transcription Factor
STAT3 Transcription Factor
STAT4 Transcription Factor
STAT5 Transcription Factor
STAT6 Transcription Factor
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