Mesh term Apoptosis Inducing Factor
Browse to parent terms:Apoptosis Regulatory Proteins
Flavoproteins
NADH, NADPH Oxidoreductases
Poly-ADP-Ribose Binding Proteins
Description
A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.Search for this term in our Faculty Database
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