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Mesh term Proto-Oncogene Proteins c-ret

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Cadherin Related Proteins
Proto-Oncogene Proteins
Receptor Protein-Tyrosine Kinases

Description

Receptor protein-tyrosine kinases involved in the signaling of GLIAL CELL-LINE DERIVED NEUROTROPHIC FACTOR ligands. They contain an extracellular cadherin domain and form a receptor complexes with GDNF RECEPTORS. Mutations in ret protein are responsible for HIRSCHSPRUNG DISEASE and MULTIPLE ENDOCRINE NEOPLASIA TYPE 2.



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