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Mesh term Von Hippel-Lindau Tumor Suppressor Protein

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Tumor Suppressor Proteins
Ubiquitin-Protein Ligases

Description

A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.



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