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Mesh term DAX-1 Orphan Nuclear Receptor

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Co-Repressor Proteins
Orphan Nuclear Receptors

Description

An orphan nuclear receptor that is implicated in regulation of steroidogenic pathways. It is unlike most orphan nuclear receptors in that it appears to lack an essential DNA-binding domain and instead acts as a transcriptional co-repressor. Mutations in the gene Dax-1 cause congenital adrenal hypoplasia.



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