Mesh term Axin Signaling Complex
Browse to parent terms:Intracellular Signaling Peptides and Proteins
Multiprotein Complexes
Description
A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.Browse to child terms:
Adenomatous Polyposis Coli Protein
Axin Protein
Casein Kinase I
Glycogen Synthase Kinase 3
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