Mesh term Filamins
Browse to parent terms:Actin Cytoskeleton
Contractile Proteins
Microfilament Proteins
Description
A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.Search for this term in our Faculty Database
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