Treatment of intestinal ischemia with oxygenated intraluminal perfluorocarbons. Am J Surg 1987 Mar;153(3):291-4
Date
03/01/1987Pubmed ID
3826511DOI
10.1016/0002-9610(87)90606-4Scopus ID
2-s2.0-0023158869 (requires institutional sign-in at Scopus site) 44 CitationsAbstract
Liquid perfluorocarbons are biologically inert compounds capable of dissolving up to 40 percent oxygen by volume. This remarkable and reversible oxygen solubility has encouraged investigations into therapeutic application in situations where tissue oxygen delivery is impaired. One such setting is intestinal ischemia. Identically prepared devascularized segments of rat intestine were treated with either intraluminal oxygenated perfluorocarbon (perfluorotributylamine) or physiologic saline solution. After timed sacrifice, blinded quantitative histologic evaluation for ischemic injury was performed. The perfluorotributylamine treatment groups had histologic scores indicative of less severe injury between 1 and 4 hours. These scores achieved statistical significance (p less than 0.05). We conclude that intraluminal oxygenated perfluorocarbons have a significant protective effect in this model of intestinal ischemia. This quantitative analysis is unique and is an important aspect of the preclinical evaluation of the perfluorocarbon preparations.
Author List
Oldham KT, Guice KS, Gore D, Gourley WK, Lobe TEAuthor
Keith Oldham MD Emeritus Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsFluorocarbons
Intestines
Ischemia
Male
Rats
Rats, Inbred Strains
