A technique for isolated hyperthermic liver perfusion. J Surg Oncol 1984 Nov;27(3):141-5
Date
11/01/1984Pubmed ID
6492809DOI
10.1002/jso.2930270303Scopus ID
2-s2.0-0021676791 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
Hyperthermia, either alone or combined with chemotherapy, has been shown to be effective in treating cancer. Because some investigators believe that regional hyperthermia may be more effective than whole body hyperthermia, we developed a technique to heat only the liver to 42-43 degrees for 4 hr. The procedure was adapted from a previously described animal model and was performed in four humans. Vascular isolation of the liver was accomplished by cannulating the hepatic artery, the portal vein, and the inferior vena cava followed by occluding the suprahepatic vena cava and the liver was then perfused with blood and nutrients from an oxygenated reservoir. Preliminary results show radiologic and histologic evidence of tumor necrosis or cessation of tumor growth in three of the patients. We believe this technique is safe enough for clinical experimental use and deserves further investigation.
Author List
Quebbeman EJ, Skibba JL, Petroff RJ JrAuthor
Edward J. Quebbeman MD Emeritus Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultChemotherapy, Cancer, Regional Perfusion
Female
Humans
Hyperthermia, Induced
Liver Neoplasms
Male
Middle Aged
