Stability of fluorouracil in plastic containers used for continuous infusion at home. Am J Hosp Pharm 1984 Jun;41(6):1153-6
Date
06/01/1984Pubmed ID
6741959Scopus ID
2-s2.0-0021246270 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
The stability of fluorouracil when prepared and stored in plastic containers used for continuous infusion in home therapy was studied. Fluorouracil was diluted with 5% dextrose injection. Samples were stored for 16 weeks at 5 degrees C and room temperature in polyvinyl chloride drug reservoirs and at 5 degrees C in elastomeric balloons used in a disposable drug pump. Periodically, samples were tested by a stability-indicating high-performance liquid chromatography (HPLC) assay. At 5 degrees C, there was no significant degradation. At room temperature, there was a progressive increase in fluorouracil concentration, presumably because of evaporation of water. A 10% change in the fluorouracil concentration over 55 days was predicted. Fluorouracil is stable in 5% dextrose injection for at least 16 weeks when stored at 5 degrees C in the two types of containers studied.
Author List
Quebbeman EJ, Hamid AA, Hoffman NE, Ausman RKAuthor
Edward J. Quebbeman MD Emeritus Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
BromouracilChromatography, High Pressure Liquid
Drug Packaging
Drug Stability
Fluorouracil
Home Care Services
Hot Temperature
Infusions, Parenteral
Plastics
Spectrophotometry, Ultraviolet
Time Factors
