Medical College of Wisconsin
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Application of genetic screening information to the management of medullary thyroid carcinoma and multiple endocrine neoplasia type 2. Endocrinol Metab Clin North Am 1996 Mar;25(1):1-25

Date

03/01/1996

Pubmed ID

8907678

DOI

10.1016/s0889-8529(05)70310-8

Scopus ID

2-s2.0-0029885662 (requires institutional sign-in at Scopus site)   61 Citations

Abstract

Application of RET proto-oncogene mutation analysis to the clinical management of MEN 2 and FMTC has simplified and enhanced the power of earlier used screening and treatment efforts for hereditary MTC. The approaches outlined herein are cost-effective, have improved diagnostic accuracy, and hold the promise of improved cure rates for this neoplasm. Further studies to elucidate the mechanism by which these activating mutations cause transformation may lead to other strategies for prevention or treatment of this neoplasm.

Author List

Wohllk N, Cote GJ, Evans DB, Goepfert H, Ordonez NG, Gagel RF

Author

Douglas B. Evans MD Chair, Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Base Sequence
Carcinoma, Medullary
Genetic Testing
Humans
Molecular Sequence Data
Multiple Endocrine Neoplasia Type 2a
Mutation
Pedigree
Proto-Oncogenes
Thyroid Neoplasms