A comparison of ampicillin/sulbactam and cefoxitin in the treatment of bacterial skin and skin-structure infections. Adv Ther 1994;11(4):183-91
Date
06/07/1994Pubmed ID
10150262Scopus ID
2-s2.0-0028049449 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
Seventy-six hospitalized patients with complicated skin/soft-tissue infections were enrolled in this randomized, prospective, third-party-blinded, comparative study of the effectiveness and safety of intravenous or intramuscular administration of ampicillin/sulbactam (1.0 to 2.0 g ampicillin plus 0.5 to 1.0 g sulbactam every 6 hours) and cefoxitin (1.0 to 2.0 g every 6 hours). Twenty-five of 36 ampicillin/sulbactam patients and 33 of 39 cefoxitin patients were evaluable. Clinical and bacteriologic effectiveness did not differ significantly between the two treatment groups (P = .674, P = .118, respectively); neither did duration of hospitalization (P = .894). Twenty-one (84%) ampicillin/sulbactam patients were cured, 2 (8%) were improved, and 2 (8%) were treatment failures. Twenty-eight (85%) cefoxitin patients were cured, 4 (12%) were improved, and 1 (3%) was a treatment failure. All primary pathogens were eradicated in 6 (24%) ampicillin/sulbactam patients; partial eradication occurred in 9 (36%). Primary pathogens were eradicated in 15 (47%) cefoxitin patients and partially eradicated in 8 (25%). Both treatments were well tolerated, with a small number of adverse reactions in each group. The overall incidence of adverse events was similar in the two groups.
Author List
Weigelt JAMESH terms used to index this publication - Major topics in bold
AdultAmpicillin
Cefoxitin
Female
Humans
Male
Middle Aged
Skin Diseases, Bacterial
Sulbactam
Treatment Outcome
