Total antioxidant capacity of colon in patients with chronic ulcerative colitis. Dig Dis Sci 2000 Sep;45(9):1814-9
Date
10/29/2000Pubmed ID
11052325DOI
10.1023/a:1005517824877Scopus ID
2-s2.0-0033790102 (requires institutional sign-in at Scopus site) 65 CitationsAbstract
It has been proposed that oxidative stress is involved in the pathophysiology of ulcerative colitis. We have reported the depletion of the nonenzymatic antioxidant, glutathione, in colon from active and inactive ulcerative colitis. The colon contains several biochemically linked antioxidant systems. We hypothesized that diminished total antioxidant capacity in active ulcerative colitis would be associated with increased colonic lipid peroxidation. This study was designed to determine total antioxidant capacity and lipid hydroperoxide levels using colon obtained at surgery from controls (N = 16; 4 females, 12 males; mean age 70 years), and active and inactive ulcerative colitis (N = 15; 3 females, 12 males; mean age 39). Total antioxidant capacity of control colon was higher in muscularis externa compared to the mucosal-submucosal layer (P < 0.05). There were no differences in colonic total antioxidant capacity or lipid hydroperoxide levels comparing control colon to inactive and active ulcerative colitis. The results did not support depletion of tissue total antioxidant capacity by free radicals. Depletion of glutathione in ulcerative colitis may be a specific disorder rather than a secondary defect attributable to global oxidative stress. Nonspecific antioxidant supplements appear unlikely to be beneficial in the treatment of ulcerative colitis.
Author List
Koch TR, Yuan LX, Stryker SJ, Ratliff P, Telford GL, Opara ECMESH terms used to index this publication - Major topics in bold
AdultAged
Antioxidants
Chronic Disease
Colitis, Ulcerative
Colon
Female
Humans
In Vitro Techniques
Intestinal Mucosa
Lipid Peroxides
Male
