Faculty Collaboration Database

Tracing expert thinking in clinical trial design. Comput Biomed Res 1989 Apr;22(2):190-208

Date

04/01/1989

Pubmed ID

2656077

DOI

10.1016/0010-4809(89)90025-6

Scopus ID

2-s2.0-0024541852 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

This paper describes a method for the analysis of the clinical trial design process used by experts. With this procedure, the scientific ideas and their sources can be identified and related to the clinical trial protocol actually prepared by the experts. An example is given using the work of the Intergroup Rhabdomyosarcoma Study Committee (IRS). That committee has been the primary contributor of information dealing with the treatment of rhabdomyosarcoma in children. The IRS-III protocol was used in this analysis of expert behavior because the protocol was adopted by the leading pediatric oncology clinical trial groups in North America and Europe. The analysis showed that the experts rely heavily, for much of the design, on ideas presented in numerical displays in published documents. Further, those aspects of the design which are innovative can be traced and better understood by applying the new procedure.

Author List

Malogolowkin MH, Horowitz RS, Ortega JA, Siegel SE, Hammond GD, Weiner JM

MESH terms used to index this publication - Major topics in bold

Clinical Trials as Topic
Expert Systems
Humans
Information Systems