Nonrandom chromosome alterations in rhabdomyosarcoma. Cancer Genet Cytogenet 1985 Apr 01;16(3):189-97
Date
04/01/1985Pubmed ID
3978590DOI
10.1016/0165-4608(85)90045-7Scopus ID
2-s2.0-0021815586 (requires institutional sign-in at Scopus site) 68 CitationsAbstract
Chromosome banding analysis was attempted on tumor cells from a total of six rhabdomyosarcomas. Results revealed a variety of chromosome alterations, including frequent structural rearrangement of chromosome #1 and the finding in one patient of multiple double minutes. The single chromosome most consistently involved in structural rearrangements was #3. Simple deletion or translocation of either the long or short arm of chromosome #3 was found in all rhabdomyosarcoma tumors examined in this report. Further, a review of the limited previous literature on rhabdomyosarcoma provided further support for the frequent alteration of chromosome #3 in this disease. Results from our study provide preliminary evidence that alterations of chromosome 3p14-21 may represent a site of nonrandom chromosome change in rhabdomyosarcoma.
Author List
Trent J, Casper J, Meltzer P, Thompson F, Fogh JAuthor
James Casper MD Emeritus Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Chromosome AberrationsChromosomes, Human, 1-3
Humans
Karyotyping
Rhabdomyosarcoma
Translocation, Genetic
