Receptor specificity of the antiarrhythmic effect produced by opioid peptides Dalargin and DADLE during myocardial reperfusion. Bull Exp Biol Med 2002 Apr;133(4):336-8
Date
07/19/2002Pubmed ID
12124638DOI
10.1023/a:1016229517353Scopus ID
2-s2.0-0036554835 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
Nonselective agonists of mu- and delta-opioid receptors dalargin (D-Ala2,Leu5,Arg6-enkephalin) and DADLE (D-Ala2,D-Leu5-enkephalin) administered immediately before coronary reperfusion in a dose of 0.1 mg/kg prevented the development of ventricular arrhythmias. Blockade of mu-opioid receptors abolished the antiarrhythmic effect of these peptides. Hence, antiarrhythmic activity of dalargin and DADLE is primarily associated with activation of mu-opioid receptors.
Author List
Naryzhnaya NV, Maslov LN, Lishmanov YB, Gross GJMESH terms used to index this publication - Major topics in bold
AnimalsEnkephalin, Leucine-2-Alanine
Male
Myocardial Reperfusion
Rats
Receptors, Opioid, delta
Receptors, Opioid, mu
