Subcutaneous plasmacytomas with tropism to sites of previous trauma in a multiple myeloma patient treated with an autologous bone marrow transplant. Am J Hematol 2003 Apr;72(4):274-7
Date
04/01/2003Pubmed ID
12666140DOI
10.1002/ajh.10296Scopus ID
2-s2.0-0037380242 (requires institutional sign-in at Scopus site) 36 CitationsAbstract
We report the case of a 59-year-old woman with Durie-Salmon stage IIIB IgGkappa multiple myeloma (MM), who presented 83 days after autologous hematopoietic stem cell transplant (HSCT) with multiple subcutaneous plasmacytomas. These lesions were confined exclusively to sites where the patient had sustained local trauma. The patient had no pre-transplant history of extramedullary disease and no evidence of plasma cells in the peripheral blood at any time throughout the course of her disease. This case represents the first report of refractory MM presenting as multiple subcutaneous plasmacytomas with specific tropism to sites of previous trauma. Selection of tumor cell subclones with unique chemokine receptor expression profiles that may explain this clinical observation is discussed.
Author List
Rosenblum MD, Bredeson CN, Chang CC, Rizzo JDAuthor
J. Douglas Rizzo MS, MD Director, Center Associate Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Bone Marrow TransplantationCatheterization, Central Venous
Cell Movement
Chemokines
Fatal Outcome
Female
Head and Neck Neoplasms
Humans
Injections, Intravenous
Injections, Subcutaneous
Middle Aged
Multiple Myeloma
Neoplastic Stem Cells
Organ Specificity
Phlebotomy
Recurrence
Skin
Skin Neoplasms
Transplantation, Autologous
